SPINAL CORD COMPRESSION BY METASTATIC THORACIC SPINE PARAGANGLIOMA

Authors

  • Noman Ahmed Jang Khan Dow Medical College
  • Saad Ullah
  • Hafiz Umair Siddiqui
  • Arsalan Karim

Abstract

Paragangliomas are rare neuroendocrine tumours most commonly located in the adrenal glands. The overall incidence of paragangliomas is 0.8 per 100,000 persons, but the incidence of malignant paraganglioma was found to be 93 cases out of 400 million persons in United States. We present a case of 50 year old male who came to the hospital with back pain and progressive bilateral lower limb weakness for the past 6 months. Imaging studies revealed enhancing lesions on dorsal spines. Bone scintigraphy showed increased tracer uptake at multiple sites. Bone biopsy and immune-histochemical staining proved metastatic paraganglioma. After a thorough literature search only few cases of metastatic spine paraganglioma causing spinal cord compression have been reported to date.

Keywords: Paraganglioma; spinal cord compression

References

Erickson D, Kudva YC, Ebersold MJ, Thompson GB, Grant CS, van Heerden JA, et al. Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab 2001;86(11):5210-6.

Bravo EL. Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. Endocr Rev 1994;15(3):356-68.

Beard CM, Sheps SG, Kurland LT, Carney JA, Lie JT. Occurrence of pheochromocytoma in Rochester, Minnesota, 1950 through 1979. Mayo Clin Proc 1983;58(12):802-4.

Welander J, Soderkvist P, Gimm O. Genetics and clinical characteristics of hereditary pheochromocytomas and paragangliomas. Endocr Relat Cancer 2011;18(6):R253-76.

Mornex R, Badet C, Peyrin L. Malignant pheochromocytoma: a series of 14 cases observed between 1966 and 1990. J Endocrinol Invest 1992;15(9):643-9.

Korevaar TI, Grossman AB. Pheochromocytoma and paraganglioma : assessment of malignant potential. Endocrine 2011;40(3):354-65.

Boedeker CC, Neumann HP, Maier W, Bausch B, Schipper J, Ridder GJ. Malignant head and neck paragangliomas in SDHB mutation carriers. Otolaryngol Head Neck Surg 2007;137(1):126-9.

Lenders JW, Eisenhofer G, Mannelli M, Pacak K. Phaeochromocytoma. Lancet 2005;366(9486):665-75.

Davis P, Peart WS, Van't Hoff W. Malignant phaeochromocytoma with functioning metastases. Lancet 1955;269(6884):274-5.

Mukherjee JJ, Kaltsas GA, Islam N, Plowman PN, Foley R, Hikmat J, et al. Treatment of metastatic carcinoid tumours, phaeochromocytoma, paraganglioma and medullary carcinoma of the thyroid with 131I-meta-iodobenzylguanidine (131I-mIBG). Clin Endocrinol (Oxf) 2001;55(1):47-60.

Waldherr C, Pless M, Maecke HR, Haldemann A, Mueller-Brand J. The clinical value of [90Y-DOTA]-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study. Ann Oncol 2001;12(7):941-5.

Pacak K, Eisenhofer G, Ahlman H, Bornstein SR, Gimenez-Roqueplo AP, Grossman AB, et al. Pheochromocytoma: recommendations for clinical practice from the First International Symposium. Nat Clin Pract Endocrinol Metab 2007;3(2):92-102.

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Published

2016-08-28

How to Cite

Khan, N. A. J., Ullah, S., Siddiqui, H. U., & Karim, A. (2016). SPINAL CORD COMPRESSION BY METASTATIC THORACIC SPINE PARAGANGLIOMA. Journal of Ayub Medical College Abbottabad, 28(3), 617–619. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/865

Issue

Vol. 28 No. 3 (2016): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

CASE REPORT

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