RELATIONSHIP OF SERU M VISFATIN LEVELS WI TH SERUM ELECTROLYTES, LIVER PROFILE, HEPATIC ENZ YMES AND ANTHROPOMETRIC PARAM ETERS IN PREGNANT WO MEN WITH PREECLAMPSIA AND ECL AMPSIA DURING 3RD TR IMESTER

Authors

  • Asmat Shaheen Khyber Medical University, Institute of Medical Science, Kohat
  • Muhammad Waqas Luqman Khyber Medical University, Institute of Medical Sciences Kohat
  • Sofia Iqbal District Headquarter Hospital, Karak
  • Nida Khan Hayatabad Medical Complex, Peshawar
  • Sadia Fatima Khyber Medical University, Institute Basic Medical Sciences, Peshawar
  • Rubina Nazli Khyber Medical University, Institute Basic Medical Sciences, Peshawar

DOI:

https://doi.org/10.55519/JAMC-01-8975

Abstract

Background: Eclampsia and preeclampsia are among the serious complications of gestation and threaten the lives of both mother and foetus. A protein called visfatin, one of these adipokines, is evaluated for its effects on serum electrolytes, lipid profile and hepatic enzymes in preeclamptic and eclamptic patients. Methods: A sum of 234 pregnant women were enrolled in this cross-sectional study and divided in to 2 main groups, i.e., Group A (eclamptic/preeclamptic) Group B (control) pregnant women respectively. Serum visfatin levels (ng/mL), serum electrolytes and liver enzymes were determined for every patient, using relative diagnostic kits. Anthropometric measurements were also noted. Results: A total of 234 women (cases; n=160, controls; n=74) with gestation age of ‰¥20 weeks participated in this study. Group A had 86 (36.75%) women with preeclampsia and 74 (31.62%) women with eclampsia whereas Group B had 74 (31.62%) normotensive pregnant women. A strong significantly positive association was recorded for systolic (R2=78.78; p-value <0.000) and diastolic blood pressure (BP) (R2=78.52; p-value <0.000). Similar result was obtained for serum sodium ions (R2=3.09; p-value <0.002) and chloride ions (R2=7.36; p-value <0.000). Alkaline phosphatases (ALP) (R2=63.47; p-value <0.000) had also shown a strong positive and statistically significant association with visfatin levels. Conclusion: Serum visfatin significantly decreased the sodium and chloride levels whereas the levels of potassium remained unaffected. A very strong and positive association of visfatin levels with levels of bilirubin and alkaline phosphatases was also observed (ALP) but it found no effect on aspartate transferases (AST).

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Published

2022-01-01

How to Cite

Asmat Shaheen, Luqman, M. W., Sofia Iqbal, Nida Khan, Sadia Fatima, & Rubina Nazli. (2022). RELATIONSHIP OF SERU M VISFATIN LEVELS WI TH SERUM ELECTROLYTES, LIVER PROFILE, HEPATIC ENZ YMES AND ANTHROPOMETRIC PARAM ETERS IN PREGNANT WO MEN WITH PREECLAMPSIA AND ECL AMPSIA DURING 3RD TR IMESTER. Journal of Ayub Medical College Abbottabad, 34(1), 62–66. https://doi.org/10.55519/JAMC-01-8975

Issue

Vol. 34 No. 1 (2022): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

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ORIGINAL ARTICLE

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