LOW SEX HORMONE BINDING GLOBULIN: A POTENTIAL PREDICTOR OF FUTURE GLUCOSE DYSREGULATION IN WOMEN

Authors

  • Adrian Heald Salford Royal Hospital
  • Aamir Department of Diabetes, Endocrinology and Metabolic Diseases, Hayatabad Medical Complex, Peshawar, Pakistan
  • Ian Laing Department of Clinical Biochemistry, Royal Preston Hospital, UK
  • Simon G Anderson University of the West Indies, Cavehill Campus Barbados;
  • Mark Livingston

Keywords:

SHBG, non-diabetic hyperglycaemia, Type 2 diabetes, IMD

Abstract

We looked at the relation between baseline SHBG concentration and future glycaemic status over an up to 10 year period, for women who were normoglycaemic at baseline.

In multiple linear regression analysis, a lower SHBG was associated with a higher fasting glucose independent of age and index of multiple deprivation (IMD).

These findings suggest that a low SHBG level, at a relatively young age is a risk marker for future impaired glucose handling in women.

References

Wallace IR, McKinley MC, Bell PM, Hunter SJ. Sex hormone binding globulin and insulin resistance. Clin Endocrinol (Oxf) 2013;78(3):321-9.

Heald AH, Anderson SG, Ivison F, Riste L, Laing I, Cruickshank JK, et al. Low sex hormone binding globulin is a potential marker for the metabolic syndrome in different ethnic groups. Exp Clin Endocrinol Diabetes 2005;113(9):522-8.

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28(7):412-9.

Karakas SE. New biomarkers for diagnosis and management of polycystic ovary syndrome. Clin Chim Acta 2017;471:248-53.

Heald AH, Livingston M, Holland D, Robinson J, Moreno GY, Donnahey G, Duff CJ, Wu P, Fryer AA. Polycystic ovarian syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care. Int J Clin Pract 2018;72(1):13046.

Deswal R, Yadav A, Dang AS. Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis. Syst Biol Reprod Med 2018;64(1):12-24.

Weykamp C, John WG, Mosca A, Hoshino T, Little R, Jeppsson JO, et al. The IFCC Reference Measurement

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Published

2021-10-28

How to Cite

Heald, A., Aamir, Laing, I., Anderson, S. G., & Livingston, M. (2021). LOW SEX HORMONE BINDING GLOBULIN: A POTENTIAL PREDICTOR OF FUTURE GLUCOSE DYSREGULATION IN WOMEN. Journal of Ayub Medical College Abbottabad, 33(4), 704–705. Retrieved from https://jamc.ayubmed.edu.pk/index.php/jamc/article/view/9443

Issue

Vol. 33 No. 4 (2021): Journal of Ayub Medical College Abbottabad

Section

LETTER TO THE EDITOR

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