MEASUREMENT OF RETINAL NERVE FIBER LAYER THICKNESS IN PATIENTS OF UNILATERAL AMBLYOPIA USING OPTICAL COHERENCE TOMOGRAPHY
AbstractBackground: The retinal changes that develop in the eyes during amblyopia are still unclear. It has been proven that thickness of the nerve fiber layer of the retina is positively correlated with refractive error. The objective of the present study was to measure the Retinal Nerve Fiber Layer Thickness (RNFLT) using Ocular Coherence Tomography (OCT) in patients of amblyopia. Method: A descriptive study was conducted in the Department of LRBT Free Eye Hospital, Lahore for 6 months. After meeting the inclusion criteria, 80 patients (40 amblyopic and 40 normal) were taken and grouped as A and B. Socio-demographic details of all the patients were recorded. They then underwent a complete ophthalmologic evaluation that included BCVA, slit lamp biomicroscopy, OCT examination was carried by TOPCON OCT. Each examination was done using the “fast retinal thickness” protocol for each test eye. Mean RNFLT was calculated for each eye. Results: The mean age of patients was 12.58±4.44 years. There were 20 (50%) males and 20 (50%) females. In amblyopic eyes, the mean RNFLT was 125.82±13.06mm while in normal eyes, the mean RNFLT was 94.82±1.11mm. The overall mean RNFLT was significantly higher in amblyopic eyes as compared to normal eyes (p<0.01), as well as significant when data was stratified for age and gender. Conclusion: There was significant difference observed in RNFLT in amblyopic eyes as compared to normal eyes. So these results can help us to enhance our knowledge and understand the causes of amblyopia hence improving diagnosis and management of disease.
Thangaraj S, Periyasamy V, Balaji R. Retinal vessel segmentation using neural network. IET Image Process 2018;12(5):669–78.
Schmucker C, Grosselfinger R, Riemsma R, Antes G, Lange S, LagrÃ¨ze W, et al. Effectiveness of screening preschool children for amblyopia: a systematic review. BMC Ophthalmol 2009;9(1):3.
Chia A, Dirani M, Chan YH, Gazzard G, Eong KGA, Selvaraj P, et al. Prevalence of amblyopia and strabismus in young Singaporean Chinese children. Invest Ophthalmol Vis Sci 2010;51(7):3411–7.
Akhgary M, Ghassemi-Broumand M, Amiri MA, Seyed MT. Prevalence of strabismic binocular anomalies, amblyopia and anisometropia. Rehabilitation Faculty of Shahid Beheshti Medical University. J Optom 2011;4(3):110–4.
Sturm V. The lazy eye-contemporary strategies of amblyopia treatment. Praxis 2011;100(4):229–35.
Vizzeri G, Weinreb RN, Gonzalez-Garcia AO, Bowd C, Medeiros FA, Sample PA, et al. Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness. Br J Ophthalmol 2009;93(6):775–81.
Alotaibi AG, Al Enazi B. Unilateral amblyopia: Optical coherence tomography findings. Saudi J Ophthalmol 2011;25(4):405–9.
Roper-Hall G. Current concepts of amblyopia: a neuro-ophthalmology perspective. Am Orthop J 2007;57(1):2–12.
France LW. Evidence-based guidelines for amblyogenic risk factors. Am Orthop J 2006;56(1):7–14.
Kiorpes L, McKeet SP. Neural mechanisms underlying amblyopia. Curr Opin Neurobiol 1999;9(4):480–6.
Yen MY, Cheng CY, Wang AG. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol Vis Sci 2004;45(7):2224–30.
Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, et al. Optical coherence tomography. Science 1991;254(5035):1178–81.
Schuman JS, Pedut-Kloizman T, Hertzmark E, Hee MR, Wilkins JR, Coker JG, et al. Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography. Ophthalmology 1996;103(11):1889–98.
Enoch JM. Receptor amblyopia. Am J Ophthalmol 1959;48(3):262–73.
Colen T, de Faber J, Lemij H. Retinal nerve fiber layer thickness in human strabismic amblyopia. Binocul Vis Strabismus Q 2000;15(2):141–7.
Altintas Ö, Yüksel N, Özkan B, Çaglar Y. Thickness of the retinal nerve fiber layer, macular thickness, and macular volume in patients with strabismic amblyopia. J Pediatr Ophthalmol Strabismus 2005;42(4):216–21.
Kee SY, Lee SY, Lee YC. Thicknesses of the fovea and retinal nerve fiber layer in amblyopic and normal eyes in children. Korean J Ophthalmol 2006;20(3):177–81.
Repka MX, Kraker RT, Tamkins SM, Suh DW, Sala NA, Beck RW, et al. Retinal nerve fiber layer thickness in amblyopic eyes. Am J Ophthalmol 2009;148(1):143–7.
Walker RA, Rubab S, Voll AR, Erraguntla V, Murphy PH. Macular and peripapillary retinal nerve fibre layer thickness in adults with amblyopia. Can J Ophthalmol 2011;46(5):425–7.
Yoon SW, Park WH, Baek SH, Kong SM. Thicknesses of macular retinal layer and peripapillary retinal nerve fiber layer in patients with hyperopic anisometropic amblyopia. Korean J Ophthalmol 2005;19(1):62–7.
Leone J, Koklanis K, Georgievski Z, Wilkinson R. Macular and retinal nerve fibre layer thickness in strabismus and anisometropic amblyopia. Binocul Vis Strabismus Q 2007;23(4):227–34.