GRANULAR CELL ASTROCYTOMA
AbstractGranular cell astrocytoma (GCA) is a rare glial neoplasm composed of abundant granular cytoplasm gives immunoreactivity for GFAP and S100 stains. We report a case of GCA in a 64 years old male presented with history of fits, right sided weakness and loss of consciousness. The microscopy showed sheets of large cells with abundant eosinophilic granular cytoplasm. No high-grade features were seen. Its differential diagnosis includes most of the benign histiocytic conditions. Granular cell astrocytoma has an aggressive clinical course and its survival rate is less than 1 year. That’s why early correct diagnosis is very essential.
Dutta R, Sharma MC, Suri V, Sarkar C, Garg A, Srivastava A, et al. Granular Cell Astrocytoma: A Diagnostic Conundrum. World Neurosurg 2020;143:209–13.
Choi CH, Kim KH, Song JY, Choi SJ, Kim L, Park IS, et al. Construction of high-density tissue microarrays at low cost by using self-made manual microarray kits and recipient paraffin blocks. Korean J Pathol 2012;46(6):562.
Vizcaino MA, Palsgrove DN, Yuan M, Giannini C, Cabrera‐Aldana EE, Pallavajjala A, et al. Granular cell astrocytoma: an aggressive IDH‐wildtype diffuse glioma with molecular genetic features of primary glioblastoma. Brain Pathol 2019;29(2):193–204.
Schittenhelm J, Psaras T. Glioblastoma with granular cell astrocytoma features: a case report and literature review. Clin Neuropathol 2010;29(5):323–9.
Caporalini C, Buccoliero AM, Scoccianti S, Moscardi S, Simoni A, Pansini L, et al. Granular cell astrocytoma: report of a case and review of the literature. Clin Neuropathol 2016;35(4):186–93.
Ishii T, Mizukawa K, Sasayama T, Sasaki H, Hayashi S, Nakamizo S, et al. Immunohistochemical and molecular genetics study of a granular cell astrocytoma: a case report of malignant transformation to a glioblastoma. Neuropathology 2013;33(3):299–305.
Shi Y, Morgenstern N. Granular cell astrocytoma. Arch Pathol Lab Med 2008;132(12):1946–50.
Shin E, Chung CK, Park SH. Granular cell astrocytoma. Pathol Res Pract 2007;203(1):57–62.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.