• Ayma Batool Resident
  • Azra Bashir
  • Saira Javed
  • Samina Zaman
  • Akhtar Sohail Chughtai



Granular cell astrocytoma (GCA) is a rare glial neoplasm composed of abundant granular cytoplasm gives immunoreactivity for GFAP and S100 stains. We report a case of GCA in a 64 years old male presented with history of fits, right sided weakness and loss of consciousness. The microscopy showed sheets of large cells with abundant eosinophilic granular cytoplasm. No high-grade features were seen. Its differential diagnosis includes most of the benign histiocytic conditions. Granular cell astrocytoma has an aggressive clinical course and its survival rate is less than 1 year. That’s why early correct diagnosis is very essential.


Dutta R, Sharma MC, Suri V, Sarkar C, Garg A, Srivastava A, et al. Granular Cell Astrocytoma: A Diagnostic Conundrum. World Neurosurg 2020;143:209–13.

Choi CH, Kim KH, Song JY, Choi SJ, Kim L, Park IS, et al. Construction of high-density tissue microarrays at low cost by using self-made manual microarray kits and recipient paraffin blocks. Korean J Pathol 2012;46(6):562.

Vizcaino MA, Palsgrove DN, Yuan M, Giannini C, Cabrera‐Aldana EE, Pallavajjala A, et al. Granular cell astrocytoma: an aggressive IDH‐wildtype diffuse glioma with molecular genetic features of primary glioblastoma. Brain Pathol 2019;29(2):193–204.

Schittenhelm J, Psaras T. Glioblastoma with granular cell astrocytoma features: a case report and literature review. Clin Neuropathol 2010;29(5):323–9.

Caporalini C, Buccoliero AM, Scoccianti S, Moscardi S, Simoni A, Pansini L, et al. Granular cell astrocytoma: report of a case and review of the literature. Clin Neuropathol 2016;35(4):186–93.

Ishii T, Mizukawa K, Sasayama T, Sasaki H, Hayashi S, Nakamizo S, et al. Immunohistochemical and molecular genetics study of a granular cell astrocytoma: a case report of malignant transformation to a glioblastoma. Neuropathology 2013;33(3):299–305.

Shi Y, Morgenstern N. Granular cell astrocytoma. Arch Pathol Lab Med 2008;132(12):1946–50.

Shin E, Chung CK, Park SH. Granular cell astrocytoma. Pathol Res Pract 2007;203(1):57–62.