• Faheema Afsar Khan CPSP
  • Majid Hussain National University of Medical Sciences, Rawalpindi-Pakistan
  • Bushra muzaffar Khan National University of Medical Sciences, Rawalpindi-Pakistan
  • Saima afsar CPSP
  • Mairah shafique National University of Medical Sciences, Rawalpindi-Pakistan
  • Sami ul Haq CPSP
  • Nadia Akbar CPSP
  • Adeel Siddique National University of Medical Sciences, Rawalpindi-Pakistan



Background: Cryotherapy is a common destructive treatment modality for treating plantar warts that results in blistering and scarring. Mitomycin an antitumor drug with antiviral property is a safe, better and a promising option for treating plantar warts. Objective was to compare efficacy of cryotherapy and mitomycin microneedling in the management of plantar warts. It was a randomized controlled trial conducted at the Skin Department CMH Abbottabad from 1st May to 31st December 2021. Methods: The study included 60 patients with plantar warts. Each group with 30 patients. Random tables were used to determine the distribution of patients within each group. Group A received mitomycin microneedling (1u/ml) repeated every 3 weeks. Group B was prescribed liquid nitrogen cryotherapy. The freeze-thaw cycle was 20 secs and repeated every 2 weeks. Both groups were treated for 4 months duration were. For analysis of data, SPSS version 21.0 was used. Efficacy was compared by the application of Chi-square test between the two groups. p<0.05 was considered statistically significant. Results: Mitomycin microneedling completely cured 76.7% of patients, while cryotherapy was effective for only 56.7%. Complete remission was observed after two to three sessions of mitomycin microneedling while average of 4 sessions of cryotherapy were required for complete remission. In general, microneedling with mitomycin had better tolerance, pain being the commonest adverse effect. Conclusion: Plantar warts can be effectively treated with mitomycin microneedling. Treatment of plantar warts with this method is more effective, requires fewer sessions, and may take less time to complete.

Author Biographies

Faheema Afsar Khan, CPSP


Majid Hussain, National University of Medical Sciences, Rawalpindi-Pakistan


Bushra muzaffar Khan, National University of Medical Sciences, Rawalpindi-Pakistan


Saima afsar, CPSP


Mairah shafique, National University of Medical Sciences, Rawalpindi-Pakistan


Sami ul Haq, CPSP


Nadia Akbar, CPSP


Adeel Siddique, National University of Medical Sciences, Rawalpindi-Pakistan



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