SPECIFIC SERUM IMMUNOGLOBULIN G TO CHLAMYDIA PNEUMONIAE IN HEALTHY CHILDREN AND ADULTS (SOUTH-EAST OF IRAN)

Authors

  • Maryam Nemati Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman
  • Vahid Mirzaee Department of Internal Medicine, Ali-ebne-Abilaleb Hospital, Rafsanjan University of Medical Sciences, Rafsanjan
  • Ziba Shaabani Department of Internal Medicine, Ali-ebne-Abilaleb Hospital, Rafsanjan University of Medical Sciences, Rafsanjan
  • Moein Zarrin Department of Internal Medicine, Ali-ebne-Abilaleb Hospital, Rafsanjan University of Medical Sciences, Rafsanjan
  • Sayed Ali Mirabdolahi Department of Microbiology and Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan
  • Masoomeh Bagheri-Jamebozorgi Department of Microbiology and Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan
  • Mohammad-Taghi Rezayati Department of Microbiology and Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan
  • Abdollah Jafarzadeh Department of Microbiology and Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan

Abstract

Background: Chlamydia pneumoniae (C. pneumonia) is an obligate intracellular bacterium and recognized as a risk factor for several diseases such as asthma, atherosclerosis and arthritis. The aim of this study was to determine the sero-prevalence of C. pneumonia in healthy subjects in different age groups. Methods: The serum levels of anti C. pneumonia IgG were measured by using of ELISA. Results: Totally, 630 subjects (164 children and 466 adults) were included into study. The sero-prevalence and the mean titer of anti C. pneumonia antibody were 11.3% and 14.48±2.18 RU/mL;  at age ≤10 years, 15% and 17.47±2.40 RU/mL  at age 11–20 years, 21% and 25.15±4.56 RU/mL  at age 21–30 years group, 40% and 53.77±6.40 RU/mL  at age 31–40 years, 94% and 146.41±8.95 RU/mL  at age 41–50 years, 98% and 153.59±10.38 RU/mL  at age 51–60 years, 96% and 138.80±12.78 RU/mL  at age 61–70 years, respectively. The differences of the sero-prevalence and the mean titer of anti C. pneumonia antibody between age groups were significant (p<0.0001). The sero-prevalence and the mean titer of anti C. pneumonia antibody were 11.6% and 14.33 ± 1.49 RU/mL in children and 65.5% and 97.40±4.46 RU/mL in adults. The sero-prevalence and the mean titer of anti C. pneumonia antibody were significantly higher in adults in comparison with those in children (p<0.0001). Conclusion: These findings showed that the sero-prevalence and titer of anti C. pneumonia IgG were increased with advanced ages and were higher in adults as compared to children.  Keywords: Chlamydia pneumonia; IgG; Sero-prevalence; Age; Adults; Children; Iran

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Published

2015-06-20