CHROMOBLASTOMYCOSIS: A RARE PRESENTATION WITH POLYMORPHIC CUTANEOUS LESIONS AND BONE INVOLVEMENT, CAUSED BY EXOPHIALA JANSELMEI
DOI:
https://doi.org/10.55519/JAMC-03-11220Keywords:
Chromoblastomycosis, cutaneous and bone involvement, Exophiala Janselmei, combination antifungals, polymorphic cutaneous lesionsAbstract
Chromoblastomycosis, a chronic fungal infection of skin and subcutaneous tissue arises as a result of traumatic inoculation of exposed areas of body. We present a unique case of chromoblastomycosis caused by Exophiala janselmei in a female farmer who presented with multiple smooth non tender nodules on trunk and limbs for 5 years and pigmented indurated plaques on face for 2 years along with deformities of hands. Imaging investigations revealed multiple lytic lesions in the bones of upper and lower limbs. Histopathological findings showed characteristic sclerotic bodies, consistent with the diagnosis of chromoblastomycosis. She was started on combination of oral antifungals with good response. This case highlights the importance of high suspicion and early diagnosis of deep fungal infections in order to avoid disfigurement and comorbidities.References
Krzyściak PM, Pindycka-Piaszczyńska M, Piaszczyński M. Chromoblastomycosis. Adv Dermatol Allergol Dermatol Alergol 2014;31(5):310–21.
Agarwal R, Singh G, Ghosh A, Verma KK, Pandey M, Xess I. Chromoblastomycosis in India: Review of 169 cases. PLoS Negl Trop Dis 2017;11(8):e0005534.
Javaid S, Batool S, Aman S. Chromoblastomycosis with skeletal involvement: A case report. J Pak Assoc Dermatol 2016;26(4):379–82.
Khan S, Khan M, Khan F, Ahmad Z, Zia-Ur-Rehman A. A Rare Case of Chromoblastomycosis in a 12-year-old boy. J Pak Med Assoc 2019;69(9):1390–3.
Kelmer S, Oliveira J, Lyra M, Bizerra R. Chromoblastomycosis: a good treatment response to itraconazole combined with terbinafine. J Am Acad Dermatol 2011;64(2):AB107.
Gupta AK, Taborda PR, Sanzovo AD. Alternate week and combination itraconazole and terbinafine therapy for chromoblastomycosis caused by Fonsecaeapedrosoi in Brazil. Med Mycol 2002;40(5):529–34.
Additional Files
Published
Issue
Section
License
Copyright (c) 2023 Batool ur Rehman, Maria Mansoor, Humaira Talat, Reema Mirza, Farheen Ishfaq
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
