THE PATIENTS’ CHARACTERISTICS AND NON-SURGICAL TREATMENT RESULTS FOR HYPOPHARYNGEAL CANCER IN SOUTHEAST OF IRAN: A 13-YEAR STUDY

Authors

  • Mohammad Hasan Larizadeh Kerman neuroscience research center, Kerman University of Medical Sciences, Kerman-Iran
  • Aliasghar Arabi-Mianroodi Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman-Iran
  • Hadi Eslami Department of Otolaryngology, Head and Neck Surgery, Kerman University of Medical Sciences, Kerman-Iran

DOI:

https://doi.org/10.55519/JAMC-01-11408

Keywords:

Hypopharyngeal neoplasm, Hypopharyngeal neoplasm, chemoradiotherapy, survival analysis.

Abstract

Background: Various modalities have been used to treat hypopharyngeal cancer. Non- surgical modalities include radiotherapy alone, sequential chemoradiation and concomitant chemoradiation or bio radiation. This study was conducted to evaluate the primary non-surgical treatment. Methods: A total number of 67 patients treated from March 2009 to January 2022 were enrolled in this study. The 2-year and 5-year survival rates were estimated using the Kaplan-Meier method. Log-rank test was used to compare the survival outcomes according to various factors. To define independent prognostic factors, we used Cox regression analysis. Results: The mean age of the patients was 56.2 years, and 55.2% of them were male. These patients were treated by radiation alone (9 patients) or induction chemotherapy followed by either radiation (4 patients), chemoradiation (33 patients), or bio-radiation (21 patients). The mean follow-up time was 18.12 months. The 2-year and 5-year overall survival rates were estimated to be 43% and 18%, respectively. Multivariate analysis showed that T stage, N stage, and treatment modality had a statically significant relationship with overall survival. Conclusion: The results of non-surgical treatment for hypopharyngeal cancer are not satisfactory. More studies are needed to investigate the role of salvage surgery.

Author Biographies

Mohammad Hasan Larizadeh, Kerman neuroscience research center, Kerman University of Medical Sciences, Kerman-Iran

 

Aliasghar Arabi-Mianroodi, Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman-Iran

 

Hadi Eslami, Department of Otolaryngology, Head and Neck Surgery, Kerman University of Medical Sciences, Kerman-Iran

 

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Published

2023-01-15