• Shagufta Naeem Department of Pathology, Ayub Medical College Abbottabad
  • Shabana Naz Department of Pathology, Ayub Medical College Abbottabad
  • Khadija Amanullah 2Army Medical College NUMS, Islamabad
  • Hamza Javed Pakistan Red Crescent Society
  • Omair Khan Department of Forensic Medicine, Ayub Medical College Abbottabad
  • Ehtesham Ahmed Khan Afridi Department of Neurosurgery Ayub Medical College Abbottabad
  • Sikandar Ahmed Ayub Medical College Abbottabad




Fibro-adenoma breast, Estrogen receptor expression, Progesterone receptor expression, immune-histochemical staining


Background: Fibro-adenoma is the most common benign condition of the female breast comprising about 68% of all breast lumps. Fibroadenoma is an independent risk factor for the development of breast cancer. Complex fibroadenoma has a 2-3-fold increased risk ratio and simple fibroadenoma has 1.49 times increased risk ratio of developing cancer than the normal population over a period of 20 years. This study aimed to qualitatively check the frequency of oestrogen receptor-positive and progesterone receptor-positive cases of fibroadenoma in our region. Methods: This cross-sectional study was conducted in the pathology department of Ayub Medical College, Abbottabad from June 2020 to December 2021. Biopsy confirmed cases of fibroadenoma were examined using immune-histochemical stains to score qualitatively the expression pattern of ER and PR. Data was analyzed and assessed using SPSS version 25. A p-value of ≤0.05 was considered statistically significant. Results: The mean age of patients who presented with fibro-adenoma was 24.5±9.29 years with a median age of 21.5 years. In most cases, oestrogen receptor expression was mild 23 (54.76%) whereas progesterone receptor expression was severe 19 (45.23%). On chi-square test, the pattern of progesterone receptor expression for the category of hormone intake showed significant differences. Whereas, the pattern of oestrogen receptor expression for the categories of marital status, history of hormone intake, history of menstrual cycle and type of fibroadenoma showed no statistically significant difference. Conclusion: Further study into the pathogenesis of fibroadenoma is required to understand the role of ER and PR and explore the therapeutic potential of such drugs that affects these receptors.



: Kumar, V., Abbas, A. And Aster, J., 2020. Robbins & Cotran Pathologic Basis Of Disease. 10th ed. Philadelphia: ELSEVIER - HEALTH Science, pp.1037-64.

: Rihana Begum P, Thomus R, Babu N. Chances of breast cancer with fibroadenoma-Review. Journal of Scientific and Innovative Research. 2017;6(2):84-6.

: Kalim M, Hamdullah, Ahmad S, Shah FO, Yosaf M. Frequency of fibroadenoma in patients presenting with breast lump. J Postgrad Med Inst 2018; 32(1): 95-8.

: Lee M, Soltanian HT. Breast fibroadenomas in adolescents: current perspectives. Adolescent health, medicine and therapeutics. 2015;6:159.

: Loke BN, Nasir ND, Thike AA, Lee JY, Lee CS, Teh BT, Tan PH. Genetics and genomics of breast fibroadenomas. Journal of Clinical Pathology. 2018;71(5):381-7.

: Dyrstad SW, Yan Y, Fowler AM, Colditz GA. Breast cancer risk associated with benign breast disease: systematic review and meta-analysis. Breast cancer research and treatment. 2015;149(3):569-75.

: Li J, Humphreys K, Ho PJ, Eriksson M, Darai-Ramqvist E, Lindström LS, Hall P, Czene K. Family history, reproductive, and lifestyle risk factors for fibroadenoma and breast cancer. JNCI Cancer Spectrum. 2018;2(3):pky051.

: Maldi E, Sapino A. Fibroadenoma. InBreast Pathology 2019 Oct 27 (pp. 107-110). Cham: Springer International Publishing.

: Williams, N., Bulstrode, C., O'Connell, P., Bailey, H. and Love, R., 2008. Bailey & Love's Short Practice Of Surgery. 25th ed. UK: Edward Arnold (Publishers) Ltd, pp.827-50.

: Grouthier V, Chakhtoura Z, Tejedor I, Badachi Y, Goffin V, Touraine P. Positive association between progestins and the evolution of multiple fibroadenomas in 72 women. Endocrine Connections. 2020;9(6):570-7.

: Purushothaman R, Rubby SA. Clinical study on fibroadenoma of the breast. Int Surg J, 2016;3:1916-9.

: Stachs A, Stubert J, Reimer T, Hartmann S. Benign breast disease in women. Deutsches Ärzteblatt International. 2019;116(33-34):565.

: Brisken C, O’Malley B. Hormone action in the mammary gland. Cold Spring Harbor perspectives in biology. 2010;2(12):a003178.

: Talukdar MM, Ahmed N, Azad MA, Khan ME, Chowdhury F, Lima IJ, Parvin S. Hormonal Status of Females in Reproductive Age Group with Benign Breast Disease: A Study of 150 Cases. Journal of Shaheed Suhrawardy Medical College. 2016;8(2):54-7.

: Branchini G, Schneider L, Cericatto R, Capp E, Brum IS. Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas. Endocrine. 2009;35(3):459-66.

: Cericatto R, Pozzobon A, Morsch DM, Menke CH, Brum IS, Spritzer PM. Estrogen receptor-α, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: Association with nodule size, hormonal and reproductive features. Steroids. 2005;70(3):153-60.

: Ngbea JA, Vhritehire RA, Ojo BA, Akpor IO, Nyaga T, Ugbaje BA, Gyenger TD, Jegede OO. A Clinicopathologic Review of Fibroadenoma in Makurdi, North-Central Nigeria. Journal of BioMedical Research and Clinical Practice. 2018;1(1):81-6.

: Popli V, Popli MB. Juvenile Fibroadenoma at Menarche: A Case Series. Journal of Diagnostic Medical Sonography. 2019;35(3):225-8.

: Fitri AE, Khambri D. Risk Factor Analysis Of Fibroadenoma Mammae In Adolescent Girls In 2021. Science Midwifery. 2022;10(2):1788-92.

: Gautam V, Khanna C, Meena AK, Debnath PR. Giant juvenile fibroadenoma in a young female-A diagnostic dilemma. Indian Pediatrics Case Reports. 2021;1(2):113.

: Quzwain F. Comparison of Snail-1 and Estrogen Receptor Immunoexpression between Fibroadenomas and Phyllodes Tumors. Jurnal Kedokteran Brawijaya. 2020;31(2):100-4.

: Yadav RK, Min ZJ, Verma SK, Yadav SK, Gupta A, Dhakal D. REVIEW ON FIBROADENOMA. , IJSIT, 2019, 8(2), 295-9.

: Alipour S, Abedi M, Saberi A, Maleki-Hajiagha A, Faiz F, Shahsavari S, Eslami B. Metformin as a New Perspective in the Medical Management of Breast Fibroadenoma; A Randomized Clinical Trial Study.

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