• Sobia Wali Muhammad Liaquat University of Medical and Health Sciences, Jamshoro-Pakistan
  • Nadia Hassan Dow University of Health Sciences, Karachi-Pakistan
  • Samra Khan International Center for Chemical and Biological Sciences, University of Karachi-Pakistan
  • Atia Gohar Dow Institute of Biology and Advance Research, Karachi-Pakistan



Pyoderma gangrenosum; Systemic management; Refractory; Immunosuppressive


The first description of Pyoderma gangrenosum (PG) was made about a century ago. It is difficult to understand the aetiology, pathophysiology, and therapy of PG. This disease is believed to be caused by a systemic inflammatory response to neutrophil chemotaxis and faulty innate immune system control. Nearly fifty percent of the cases have underlying systemic symptoms. Significant improvements in PG management have been made over the years. The main goals of treatment are to reduce inflammation and speed up the healing of the PG wound. Even though the most recent medicines show promise, they are found on isolated case reports. The majority of patients are typically managed with topical treatment and local wound care, while resistant cases necessitate immunosuppressive medications. More progress can be made with improvements in technology in deciphering this complex disease and getting a greater understanding of the condition. The present standard therapies for refractory PG are not well supported by studies. In refractory PG, corticosteroids and cyclosporine have historically been administered. Tumour necrosis factor inhibitors are becoming a viable option; nonetheless, this requires careful research and upkeep. This review intended to describe the current trends in managing the PG. Several next-generation treatment options including the conventional therapies introduced to treat PG. We encompass the advantages and disadvantages of new treatments for PG.

Author Biographies

Sobia Wali Muhammad, Liaquat University of Medical and Health Sciences, Jamshoro-Pakistan


Nadia Hassan, Dow University of Health Sciences, Karachi-Pakistan


Samra Khan, International Center for Chemical and Biological Sciences, University of Karachi-Pakistan


Atia Gohar, Dow Institute of Biology and Advance Research, Karachi-Pakistan



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