• Murtaza Ali Gova National Institute of Child Health, Karachi-Pakistan
  • Noshaba Noor National Institute of Child Health, Karachi-Pakistan
  • Hira Nawaz National Institute of Child Health, Karachi-Pakistan
  • Rameen Akhter Molani Jinnah Sindh Medical University, Karachi-Pakistan



3-Methylcrotonylglycinuria is a common inborn error of metabolism (IEM) resulting from the deficiency of 3-Methylcrotonyl-CoA carboxylase (3-MCC) and its prevalence ranges from 1:2400 to 1:6800. The disease may be asymptomatic or may present with signs of "metabolic crisis". In our four and a half months old male patient, the disease manifested as fever, fits and an altered level of consciousness, along with signs and symptoms of metabolic crisis. The purpose of this case report is to highlight a clinical presentation of 3-MCG, as seen in this patient to ensure timely diagnosis and treatment.  

Author Biographies

Murtaza Ali Gova, National Institute of Child Health, Karachi-Pakistan


Noshaba Noor, National Institute of Child Health, Karachi-Pakistan


Hira Nawaz, National Institute of Child Health, Karachi-Pakistan


Rameen Akhter Molani, Jinnah Sindh Medical University, Karachi-Pakistan



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