PRIMARY OVARIAN BURKITTS LYMPHOMA

Authors

  • Zainab Jan Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar-Pakistan
  • Aakif Ullah Khan Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar-Pakistan
  • Abbas Ilyas Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar-Pakistan
  • Sidra Faiz Gynae B Unit, Hayatabad Medical Complex, Peshawar-Pakistan

DOI:

https://doi.org/10.55519/JAMC-S4-12410

Keywords:

Bcl-2; Burkitt lymphoma; chemotherapy; CHOP; Non-Hodgkin lymphoma

Abstract

Primary ovarian Burkitt lymphoma (BL) is a very rare and aggressive malignancy. We report an 18-year-old female patient who presented with a large, tender abdomen, and highly de-ranged renal and liver functions. Ultrasonography showed hepatosplenomegaly, mild ascites, dilated biliary channels and a heterogeneous pelvic mass of size ~15´10´6.4 cm. Immunohistochemical (IHC) staining of the biopsy sample excised from the left ovary demonstrated reactivity for CD20 and CD10, and negativity for CD3, Bcl-2 and TdT. The C-myc translocation was positive in 60% of tumour cells. Moreover, the proliferation index was ~90%. These features were consistent with BL. After haemodialysis, the patient was planned for multiagent chemotherapy, including cyclophosphamide, doxorubicin, vincristine and prednisone. This case supports the hypothesis that primary ovarian BL is an aggressive malignancy that appears to respond promisingly to multi-agent chemotherapy.

Author Biographies

Zainab Jan, Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar-Pakistan

 

Aakif Ullah Khan, Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar-Pakistan

 

Abbas Ilyas, Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar-Pakistan

 

Sidra Faiz, Gynae B Unit, Hayatabad Medical Complex, Peshawar-Pakistan

 

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Published

2024-01-16