WEIGHT CHANGES IN PATIENTS WITH HODGKIN LYMPHOMA FOLLOWING TREATMENT: EXPERIENCE FROM A CANCER HOSPITAL
Abstract
Background: Some recent studies have suggested that patients with Hodgkin lymphoma who undergo remission following treatment are likely to experience significant weight gain and may become overweight or obese. The association between treatment for Hodgkin lymphoma and subsequent weight gain has not been explored in Pakistan. We undertook a review of weight changes in adult Hodgkin lymphoma patients who received treatment at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore. Methods: In this longitudinal study, we collected and analysed secondary data including adult patients who received treatment for Hodgkin lymphoma at our institute from January 2010 till December 2013. We retrospectively noted baseline demographic, clinical characteristics, details about treatment received and change in weight from baseline at start of treatment to 6, 12, and 18 months after start of treatment. Results: A total of 470 patients registered for Hodgkin lymphoma at our centre. Data were available for 402 patients who were included in this study. Progressive increase in weight was observed in patients after treatment. The mean weight gain from the start of treatment to 6, 12, and 18 months was 3.1 kg, 7.1 kg, and 9.5 kg, respectively. Weight gain was not significantly associated with age or sex of patients. Weight gain was significantly associated with higher stages of cancer, response to treatment and B symptoms. Conclusion: The evaluation of Hodgkin lymphoma patients after treatment demonstrated considerable tendency for weight gain. Further work is warranted to explore this association and its impact on HL survivors.Keywords: Weight gain; Hodgkin Lymphoma; survivorsReferences
Derenzini E, Younes A. Predicting treatment outcome in classical Hodgkin lymphoma: Genomic advances. Genome Med 2011;3(4):26.
Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010;60(5):277–300.
Banerjee D. Recent advances in the Pathobiology of Hodgkin’s lymphoma: Potential impact on diagnostic, predictive, and therapeutic strategies. Adv Hematol 2011;2011:439456.
Mauch P, Ng A, Aleman B, Carde P, Constine L, Diehl V, et al. Report from the Rockefellar foundation sponsored international workshop on reducing mortality and improving quality of life in long-term survivors of Hodgkin’s disease: July 9-16, 2003, Bellagio, Italy. Eur J Haematol Suppl 2005;75(66):68–76.
de Haas EC, Oosting SF, Lefrandt JD, Wolffenbuttel BH, Sleijfer DT, Gietema JA. The metabolic syndrome in cancer survivors. Lancet Oncol 2010;11(2):193–203.
Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 1994;17(9):961–9.
Iverius PH, Brunzell JD. Obesi+ty and common genetic metabolic disorders. Ann Intern Med 1985;103(Pt 2):1050–1.
Withycombe JS, Smith LM, Meza JL, Merkle C, Faulkner MS, Ritter L, et al. Weight change during childhood acute lymphoblastic leukemia induction therapy predicts obesity: A report from the children’s oncology group. Pediatric Blood Cancer 2014;62(3):434–9.
Garmey EG, Liu Q, Sklar CA, Meacham LR, Mertens AC, Stovall MA, et al. Longitudinal changes in obesity and body mass index among adult survivors of childhood acute Lymphoblastic leukemia: A report from the childhood cancer survivor study. J Clin Oncol 2008;26(28):4639–45.
Wolk A, Gridley G, Svensson M, Nyrén O, McLaughlin JK, Fraumeni JF, et al. A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control 2001;12(1):13–21.
Lynce F, Pehlivanova M, Catlett J, Malkovska V. Obesity in adult lymphoma survivors. Leuk Lymphoma 2012;53(4):569–74.
Jones JA. Weight gain after lymphoma treatment: Fat or fiction? Leuk Lymphoma 2012;53(4):517–8.
Russell NC, Hoelscher DM, Janszen L, Rodriguez MA. Dietary and weight changes after treatments for lymphoma. Nutr Cancer 2007;57(2):168–76.
Eichenauer DA, Engert A, Andre M, Federico M, Illidge T, Hutchings M, et al. Hodgkin’s lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2014;25(suppl 3):iii70–5.
Vance V, Mourtzakis M, McCargar L, Hanning R. Weight gain in breast cancer survivors: Prevalence, pattern and health consequences. Obes Rev 2010;12(4):282–94.
den Hoed MA, Pluijm SM, de Groot-Kruseman HA, te Winkel ML, Fiocco M, van den Akker EL, et al. The negative impact of being underweight and weight loss on survival of children with acute lymphoblastic leukemia. Haematologica 2015;100(1):62–9.
Spiro SG, Silvestri GA. One Hundred years of lung cancer. Am J Respir Crit Care Med 2005;172(5):523–9.
Patel JD, Pereira JR, Chen J, Liu J, Guba SC, John WJ, et al. Relationship between efficacy outcomes and weight gain during treatment of advanced, non-squamous, non-small-cell lung cancer patients. Ann Oncol 2016;27(8):1612–9.
Power C, Miller SK, Alpert PT. Promising new causal explanations for obesity and obesity-related diseases. Biol Res Nurs 2007;8(3):223–33.
Iughetti L, Bruzzi P, Predieri B, Paolucci P. Obesity in patients with acute lymphoblastic leukemia in childhood. Ital J Pediatr 2012;38:4.
Courneya KS, Katzmarzyk PT, Bacon E. Physical activity and obesity in Canadian cancer survivors: population-based estimates from the 2005 Canadian Community Health Survey. Cancer 2008;112(11):2475–82.
Hequet O, Le QH, Moullet I, Pauli E, Salles G, Espinouse D, et al. Subclinical late Cardiomyopathy after Doxorubicin therapy for lymphoma in adults. J Clin Oncol 2004;22(10):1864–71.
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