ENDOSCOPIC ENDONASAL TRANS-SPHENOIDAL SURGERY IN PATIENTS WITH MACRO-ADENOMA EXTENT OF SURGICAL RESECTION AND RECURRENCE RATE
DOI:
https://doi.org/10.55519/JAMC-02-13485Keywords:
Macro-adenomas, Endoscopic Endonasal Trans-sphenoidal ApproachAbstract
Background: EETA has been employed for skull base tumors especially macro—adenomas, for the last decade in our setup. Here we are sharing our experience with the EETA for patients with micro-adenomas in terms of extent of tumor resection and its recurrence. The objective was to assess endoscopic endonasal trans-sphenoidal surgery in patients with macro-adenoma for extent of surgical resection and recurrence rate. Methods: This descriptive case series study was carried out from May 2021 till April 2023. Male and female patients with macroadenoma were enrolled which was diagnosed with contrast enhanced volumetric MRI brain. EETA and resection was performed. Extent of resection recurrence was confirmed on post-op MRI and follow up at 6 months respectively. Results: A total of 58 patients were enrolled. Mean age of the patients was 47.51 ± 7.93 years and male to female ratio was 1.3: 1. 42 (72.4%) tumors were non-functional. Somatotropin releasing tumor was the most common functional tumor (n = 09, 15.5%). Total resection was performed in 49 (84.4%) patients. Recurrence was observed in 09 (15.6%) cases. Conclusion: EETA has been shown to be a safe and effective technique for the resection of macroadenoma of the skull base.References
Asemota AO, Ishii M, Brem H, Gallia GL. Comparison of Complications, Trends, and Costs in Endoscopic vs Microscopic Pituitary Surgery: Analysis From a US Health Claims Database. Clin Neurosurg (2017) 81(3):458–71.
Molitch ME. Diagnosis and Treatment of Pituitary Adenomas: A Review. JAMA - J Am Med Assoc (2017) 317:516–24.
Melmed S. Mechanisms for Pituitary Tumorigenesis: The Plastic Pituitary. J Clin Invest (2003) 112:1603–18.
Melmed S. Pituitary-Tumor Endocrinopathies. Longo DL, Editor. N Engl J Med (2020) 382(10):937–50.
Suri H, Dougherty C. Clinical Presentation and Management of Headache in Pituitary Tumors. Curr Pain Headache Rep (2018) 22:1–6.
Kim SH, Lee KC, Kim SH. Cranial Nerve Palsies Accompanying Pituitary Tumour. J Clin Neurosci (2007) 14(12):1158–62.
Vernooij MW, Ikram MA, Tanghe HL, Vincent AJPE, Hofman A, Krestin GP, et al.. Incidental Findings on Brain MRI in the General Population. N Engl J Med (2007) 357(18):1821–8.
Barkhoudarian G, Palejwala SK, Ansari S, Eisenberg AA, Huang X, Griffiths CF, et al.. Rathke’s Cleft Cysts: A 6-Year Experience of Surgery vs. Observation With Comparative Volumetric Analysis. Pituitary (2019) 22(4):362–71.
Larkin S, Karavitaki N, Ansorge O. Rathke’s Cleft Cyst. In: Handbook of Clinical Neurology. Amsterdam: Elsevier B.V; (2014). p. 255–69.
Müller HL. Craniopharyngioma. Endocr Rev (2014) 35:513–43.
O’Steen L, Indelicato DJ. Advances in the Management of Craniopharyngioma [Version 1; Peer Review: 3 Approved]. F1000 Res (2018) 7.
Goffart Y, Jorissen M, Daele J, Vander Poorten V, Born J, Deneufbourg JM, et al.. Minimally Invasive Endoscopic Management of Malignant Sinonasal Tumours. Acta Otorhinolaryngol Belg (2000) 54(2):221–32.
Bogaerts S, Vander Poorten V, Nuyts S, Van Den Bogaert W, Jorisser M. Results of Endoscopic Resection Followed by Radiotherapy for Primarily Diagnosed Adenocarcinomas of the Paranasal Sinuses. Head Neck (2008) 30(6):728–36.
Van Gerven L, Jorissen M, Nuyts S, Hermans R, Vander Poorten V. Long-Term Follow-Up of 44 Patients With Adenocarcinoma of the Nasal Cavity and Sinuses Primarily Treated With Endoscopic Resection Followed by Radiotherapy. Head Neck (2011) 33(6)898–904.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Zia Ur Rahman, Muhammad Idris Khan, Muhammad Aamir
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
