• Abdul Sattar
  • Abdul Majeed Khan
  • Sadia Anjum
  • Abbas Naqvi


Background: Ultrasound guided fine needle aspiration cytology (FNAC) is a valuable technique for diagnosing benign and malignant space occupying masses of liver. It is a cost effective and safe method that can differentiate benign and malignant lesions accurately. The objective of this study was to analyse cases of radiologically guided fine needle aspiration cytology of space occupying lesions of liver. Methods: Ultrasound guided FNAC of liver masses was carried out on 450 admitted patients with focal lesions liver on ultrasound. Patients of all ages and both sexes were included. The study was conducted in department of Diagnostic radiology in collaboration with the Pathology Department at Nishtar Medical College & Hospital, Multan over a period of two years from August, 2009 to August, 2011. The aspirates were done by senior radiologist in Radiology Department. Results: Most of the aspirates were from males. Ten cases were considered inadequate. There were more malignant cases (320 cases) as compared to benign lesions (120 cases). Metastatic lesions were more common as compared to hepatocellular carcinoma (HCC); however the ratio of metastatic adenocarcinoma and primary HCC was almost equal. Conclusion: Ultrasound guided FNAC is a simple, quick and complication free procedure for diagnosing space occupying lesions of liver.Keywords: FNAC, HCC, Histopathology, liver, metastasis


Hassan SH, Ahmed R. Percutaneous fine needle aspiration biopsy cytology of liver. A review of 236 cases. Pak J Pathol 1991;2(1):13–5.

Greene CA, Suen KC. Some cytologic features of hepatocellular carcinoma as seen in fine needle aspirates. Acta Cytol 1984;28:713–8.

Pedio G, Landolt U, Zobeli L, Gut D. Fine needle aspiration of liver. Significance of hepatocytic naked nuclei in the diagnosis of hepatocellular carcinoma. Acta Cytol 1988;32:437–42.

HO CS, McLoughlin MJ, Tao LC, Blendis L, Evans WK. Guided percutaneous fine needle aspiration biopsy of liver. Cancer 1981;47:1781–5.

Pinto, MM, Avila NA, Hellr CL, Criscuolo EM. Fine needle aspiration of liver. Acta Cytol 1988;32:15–21.

Suen KC. Diagnosis of primary hepatic neoplasms by fine needle aspiration cytology. Diagn Cytopathol 1986;2:99–109.

Gatphoh ED, Gaytri S, Babina S, Singh AM. Fine needle aspiration of liver: a study of 202 cases. Indian J Med Sci.2003;57:22–5.

Rehman A, Murad S. Hepatocellular carcinoma A retrospective analysis of 118 cases. J Coll Physicians Surg Pak 2002;12:108–9

Afroz N, Khan N, Chana RS. Cytodiagnosis of yolk sac tumour. Indian J Pediatr 2004;71:939–42.

Suleman BA, Atif N, Ahmed S, Chughtai N. Analysis of 210 cases of radiologically guided FNAC of intraabdominal masses. Prceedings Shaikh Zayed Postgrad Med Inst 2004;18:35–44.

Hajdu SI, D’Ambrosio FG, Fields V, Lightdale CJ. Aspiration and brush cytology of the liver. Semin Diag pathol 1986;3:227–38.

Suleman BA, Latif A, Chughtai N, Ahmed S, Saeed M. Evaluation of ultrasound guided fine needle aspiration cytology in diagnosis of space occupying lesions of liver. Professional Med J 1995;2:276–88.

Ma TK, Tse MK, Tsui WM, Yuen KT. Fine needle aspiration diagnosis of angiomyolipoma of the liver using a cell block with immunohistochemical study. Acta Cytol 1994;38:257–60.

Tsui WM, Yuen RW, Chow LT, Tse CC. Solitary necrotic nodule of the liver: support for a parasitic origin. J Clin Pathol 1992;45:975–8.

Cohen MB, Haber MM, Holly EA, Ahn DK, Bottles K, Stoloff AC. Cytologic criteria to distinguish hepatocellular carcinoma from nonneoplastic liver. Am J Clin Pathol 1991;95:125–30.

Suen KC, Magee JF, Halparin LS, Chan NH, Greene CA. Fine needle aspiration cytology of fibrolamellar hepatocellular carcinoma. Acta Cytol 1985;29:867–72.

Sola Pérez J, Pérez-Guillermo M, Bas Bernal A, Mercader JM. Hepatoblastoma. An attempt to apply histologic classification to aspirates obtained by fine needle aspiration cytology. Acta Cytol 1994;38:175–82.

Bottles K, Cohen MB, Holly EA, Chiu SH, Abele JS, Cello JP, et al. A step-wise logistic regression analysis of hepatocellular carcinoma. An aspiration biopsy study. Cancer 1988;62:558–63.

Leong AS, Sormunen RT, Tsui WMS, Liew CT. Hep Par 1 and selected antibodies in the immunohistochemical distinction of hepatocellular carcinoma from cholangiocarcinoma, combined tumours and metastatic carcinoma. Histopathology 1998;33:318–24.



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