FREQUENCY OF GALLSTONES IN PATIENTS WITH LIVER CIRRHOSIS

Authors

  • Azhar Hussain
  • Muhammad Arif Nadeem
  • Sajid Nisar
  • Hafiza Ammarah Tauseef

Abstract

Background: Liver cirrhosis is a serious disease which can lead to liver failure. The main objective of this study was to ascertain the frequency of gallstones in patients with liver cirrhosis. Methods: One hundred and fifty patients fulfilling the inclusion criteria were selected from Medical Unit-IV for this cross sectional study. Their abdominal ultrasound was done to diagnose liver cirrhosis and to see presence of gallstones. All the patients were assessed by same sonologist. Their demographic data was entered in a specially designed pro forma. Results: Frequency of gall stones in patients with liver cirrhosis was found to be 21.6%. Conclusion: This study reveals that the gallstones are frequent in patients suffering from chronic liver disease. The frequency of gallstones increases with increase in disease duration.Keywords: Cirrhosis, Gallstones, Fibrosis, Chronic liver disease

References

Friedman LS. Liver, Biliary Tract and Pancreas. In: Tierney LM, McPhee SJ, Papadakis MA, editors. Current Medical Diagnosis and Treatment. 46th ed. New York: McGraw Hill; 2007:p. 664–718.

Par A, Par G. Liver fibrosis: pathophysiology, diagnosis and treatment. Orv Hetil 2005;146:3–13.

Khokhar N. Serum aminotransferase levels and platelet count as predictive factor of fibrosis and cirrhosis in patients with chronic hepatitis C infection. J Pak Med Assoc 2003; 53: 101–4.

Idrees M, Lal A, Naseem M, Khalid M. High prevalence of hepatitis C virus infection in the largest province of Pakistan. J Dig Dis. 2008;9:95–103.

Mohan P, Colvin C, Glymph C, Chandra RR, Kleiner DE, Patel KM, et al. Clinical spectrum and histopathologic features of chronic hepatitis C infection in children. J Pediatr 2007;150:168–74.

Nazish Z, Inayatullah M, Nasir SA, Arshad M, Tanveer S, Naqvi AB. Liver Cirrhosis; Clinical Presentation. Professional Med J 2002;9:207–12.

Johnston DE, Kaplan MM. Pathogenesis and treatment of gallstones. N Engl J Med 1993; 328:412–21.

Portincasa P, Moschetta A, Palasciano G. Cholesterol gallstone disease. Lancet 2006; 368:230–9.

Acalovschi M, Dumitrascu DL, Nicoara CD. Gallbladder contractility in liver cirrhosis: comparative study in patients with and without gallbladder stones. Dig Dis Sci 2004;49:17–24.

Fernández-Esparrach G, Sánchez-Fueyo A, Ginès P, Uriz J, Quintó L, Ventura PJ, et al. A prognostic model for predicting survival in cirrhosis with ascites. J Hepatol 2001;34:46–52.

Anderson RN. Deaths: leading causes for 2000. Natl Vital Stat Rep 2002;50:1–85.

de Franchis R, Pascal JP, Ancona E, Burroughs AK, Henderson M, Fleig W, et al. Definitions, methodology and therapeutic strategies in portal hypertension. J Hepatol 1998;15:256–61.

Shaffer EA. Gallstone disease: Epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol 2006;20:981–96.

Butt Z, Hyder Q. Cholelithiasis in hepatic cirrhosis: Evaluating the role of risk factors. J Pak Med Assoc 2010;60:641–4.

Naheed T, Akbar N, Akbar N. Frequency of Gallstones in patients of liver cirrhosis - a study in Lahore. Pak J Med Sci 2004;20:215–8.

Acalovschi M, Blendea D, Feier C, Letia AI, Ratiu N, Dumitrascu DL, et al. Risk factors for symptomatic gallstones in patients with liver cirrhosis: a case-control study. Am J Gastroenterol 2003;98:1856–60

Downloads

Published

2014-09-01