HYALINIZING TRABECULAR NEOPLASM OF THYROID
AbstractHyalinizing trabecular neoplasm (HTN) is an uncommon, controversial lesion of thyroid. In its cytological and histopathological features, HTN mimics papillary and medullary carcinoma and usually misdiagnosed on fine needle aspiration cytology specimens. Pure HTN lesions are neoplams of very low malignant potential. Hemithyroidecomy is an adequate treatment; however, misinterpretation leads to total thyroidectomy and or followed by radioactive iodine ablation therapy. Correct histopathological diagnosis potentiates conservative management. We present a case in a 32-year-old female patient with review of diagnosis, management and one year follow up.Keywords: Hyalinizing trabecular neoplasm, thyroid, papillary, medullary
Gupta S, Modi S, Gupta V, Marwah N. Hyalinizing trabecular tumour of the thyroid gland. J Cytol 2010; 27(2):63–5.
D'Elia J, Charous D, Miller J, Palazzo J, Pribitkin E. Hyalinizing trabecular neoplasm of the thyroid: Controversies in management. Internet J Endocrinol. 2005;2(1). Available at https://ispub.com/IJEN/2/1/9000
Carney JA, Ryan J, Goellner JR. Hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol. 1987;11:583–91.
DeLellis RA, Lloyd RD, Heitz PU, Eng C. WHO: Pathology and Genetics. Tumours of Endocrine Organs. In: Kleihues P, Sobin LE, editors. WHO Classification of Tumours. Lyon, France: IARC Press; 2004.p. 49–133.
Li J, Yang GZ, Gao LX, Yan WX, Jin H, Li L. Hyalinizing trabecular tumour of the thyroid: Case report and review of the literature. Exp Ther Med. 2012;3(6):1015–7.
Ting S, Puttinger C, Schmid KW, Sheu-Grabellus SY. Hyalinizing trabecular tumour of the thyroid. An overcautious designation of a benign thyroid tumour?. Pathologe 2012;33(2):135–41.
Salvatore G, Chiappetta G, Nikiforov YE, Decaussin-Petrucci M, Fusco A, Carney JA, et al. Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations. Eur J Cancer 2005;41:816–21.
Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S et al. Hyalinizing trabecular adenoma-an uncommon thyroid tumour frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg. 2007;193(6):707–12.
Casey MB, Sebo TJ, Carney JA. Hyalinizing trabecular adenoma of the thyroid gland: Cytologic features in 29 cases. Am J Surg Pathol 2004;28:859–67.
Livolsi, VA. Hyalinizing trabecular tumour of the thyroid: adenoma, carcinoma, or neoplasm of uncertain malignant potential? Am J Surg Pathol 2000; 24:1683–4.
Smith NR, Bullock MJ, Hart RD, Trites JR, Taylor SM. Hyalinizing trabecular tumour: review and new insights into the molecular biology. J Otolaryngol Head Neck Surg 2012;41(1):30–4.
Caraci P, Fulcheri A, Ondolo C, Laino F, Volante M, Aversa S. Hyalinizing trabecular tumour of the thyroid: a case report. Head Neck Pathol 2011;5(4):423–7