FREQUENCY OF SEROPOSITIVITY OF HELICOBACTER PYLORI IN PATIENTS PRESENTING WITH DYSPEPSIA
AbstractBackground: Dyspepsia is a common health problem and most of the causes of dyspepsia are related to infection by Helicobacter pylori (H. pylori). Prevalence of H. pylori infection is different in different parts of the world. Purpose of our study was to determine the frequency of H. pylori infection in patients with dyspepsia in our setting where the prevalence of H. pylori was expected to be high. Objective of this study was to determine the frequency of H. pylori seropositivity in patients with dyspepsia. Methods: A Cross sectional, descriptive study was conducted at the Department of Medicine, Ayub Medical College, Abbottabad from March to September 2009. Patients presenting in Medical outpatient departments of Ayub Teaching Hospital, Abbottabad with dyspepsia were included in the study and interviewed according to Reflux Disease Questionnaire and their serum sent for estimation of anti H. pylori IgG antibodies by enzyme linked immunosorbent assay (ELISA). Results: A total of 92 patients were included in this study. Out of these 31 (33.7 %) were males and 61 (66.3%) were females. Out of them 68 (73.9%) were found seropositive for H. pylori by ELISA. Conclusion: H. pylori infection is frequent in patients with dyspepsia in our setting and apparently uncomplicated dyspepsia should always be tested for H. pylori and all seropositive patients should be offered eradication therapy.Keywords: Helicobacter pylori (H. pylori), dyspepsia, peptic ulcer, gastritis, non-ulcer dyspepsia
Valle JD. Peptic ulcer disease and related disorders. In: Fauci S, Braunwald E, Kasper L, Hauser SL, Longo L, Jameson JL, et al editors. Harrison’s principles of internal medicine. 17th ed. New York: McGraw-Hill’s; 2008. p.1855–72.
Lane JA, Murray LJ, Nobel S, Egger M, Harvay IM, Donovan JL, et al. Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomized controlled trial. BMJ 2006;332:199–204
Kuipers EJ, Blaser MJ. Acid peptic disease: Epidemiology and pathobiology. In: Goldman L, Ausiello D, editors. Cecil Medicine. 23rd ed. Philadelphia: Elsevier, 2007; p. 994–8.
Grande M, Cadeddu F, Villa M, Attina GM, Muzi MG, Nigro C, et al. Helicobacter pylori and gastroesophageal reflux disease. World J Surg Oncol 2008;6:74–8.
Khan MQ. Helicobacter pylori Eradication Therapy in Nonulcer Dyspepsia is Beneficial. Saudi J Gastroenterol 2008;14:96–100.
Riazul-Hassan S, Abbas Z. Presence of Helicobacter pylori in dyspeptic patients with endoscopically normal stomach. Pak J Med Sci 2007;23 335–9.
Todorovic M, Balint B, Jevtic M, Suvajdzic N, Ceric A, Stamatovic D, et al. Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome. World J Gastroenterol 2008;14:2388–93.
Lassen A, Hallas J, Schaffalitzky de Muckadell OB. Helicobacter pylori test and eradicate versus prompt endoscopy for management of dyspeptic patients: 6.7 year follow up of a randomised trial. Gut 2004;53:1758–63.
Mégraud F, Lehours P. Helicobacter pylori detection and antimicrobial susceptibility testing. Clin Microbiol Rev 2007;20:280–322.
Leal YA, Flores LL, García-Cortés LB, Cedillo-Rivera R, Torres J. Antibody-based detection tests for the diagnosis of helicobacter pylori infection in children: a meta-analysis PLoS ONE 2008;3:3751–6.
Musana AK, Yale SH, Lang KA.. Managing dyspepsia in a primary care setting. Clin Med Res 2006;4:337–42.
Shaw M1, Dent J, Beebe T, Junghard O, Wiklund I, Lind T, , et al. The reflux disease questionnaire; a measure of treatment response in clinical trials. Health Qual Life Outcomes 2008;6:31–2.
Lacy BE, Rosemore J. Helicobacter pylori: ulcers and more: The beginning of an era. J Nutr 2001;131:2789S–93.
Replogle ML, Glaser SL, Hiatt RA, Parsonnet J. Biological sex as a risk factor for Helicobacter pylori infection in healthy young adults. Am J Epidemiol 1995;142:856–63.
Shiota S, Murakami K, Takayama A, Yasaka S, Okimoto T, Yoshiiwa A, et al. Evaluation of Helicobacter pylori status and endoscopic findings among new outpatients with dyspepsia in Japan. J Gastroenterol 2009;44:930–4.
Santos IS, Boccio J, Santos AS, Valle NC, Halal CS, Bachilli MC, et al. Prevalence of Helicobacter pylori infection and associated factors among adults in Southern Brazil: a population-based cross-sectional study. BMC Public Health 2005;5:118.
Rowland M, Daly l, Vaughan M, Higgins A, Bourke B, Drumm B. Age-specific incidence of Helicobacter pylori. Gastroenterology 2006;130:65–72.
Marusic M, Presecki V, Katicic M, Bilic A, Jurcic D, Schwarz D. Seroprevalence of Helicobacter pylori infection in dyspeptic patients. Coll Antropol 2008;32:1149–53.
Sood MR, Joshi S, Akobeng AK, Mitchell J, Thomas AG., Thomas A. Growth in children with Helicobacter pylori infection and dyspepsia. Arch Dis Child 2005;90:1025–8.
Malik KA, Shaikh R, Rehman S. Prevalence of Helicobacter Pylori in dyspeptic patients at Liyari General Hospital. Pak J Surg 2007;23:33–5.
Amin K, Alam Z, Nagra MH, Hussain I, Javed M. Helicobacter pylori with non-ulcer dyspepsia. Professional Med J 2003;10:208–11.
Fareed R, Abbas Z, Shah MA. Effect of Helicobacter pylori density on inflammatory activity in stomach. J Pak Med Assoc 2000;50:148–51.
Mohsin A, Qayyum A, Hussain I, Mirza A, Shah AA, Zaidi SNR. Helicobacter Pylori Prevalence and Eradication (HAPPEN) Study: Helicobacter Pylori Prevalence: An experience with patients presenting to Jinnah Hospital, Lahore. Ann King Edward Med Coll 1999;5:95–6.
Wadood A, Aziz ur Rehman, Masud U, Mirza JA, Sahibzada NJ, Aziz ur Rehman. Helicobacter associated Gastritis a clinic-pathological study at Quetta. Biomedica 1997;13:57–9.
Qureshi AF, Memon AS, Memon MA, Memon JM, Soomro AA, Shaikh MK. Incidence of Helicobacter Pylori in Gastroduodenitis. Biomedica 1996;12(1):19–21.
Hashemi MR, Rahnavardi M, Bikdeli B, Dehghani Zahedani M. H. pylori infection among 1000 southern Iranian dyspeptic patients. World J Gastroenterol 2006;12:5479–82.
Sari YS, Sander E, Erkan E, Tunali V. Endoscopic diagnosis and CLO test results in 9239 cases, prevalence of Helicobacter pylori in Istanbul, Turkey. J Gastroenterol Hepatol 2007;22:1706–11.
Akbar DH, Eltahawy AT. Helicobacter pylori infection at a university hospital in Saudi Arabia: prevalence, comparison of diagnostic modalities and endoscopic findings. Indian J Pathol Microbiol 2005;48:181–5.
Abdul Aziz AF, Hamzah Z, Tong SF, Nadeson S,Wan Puteh SE. Helicobacter pylori related dyspepsia: prevalence and treatment outcomes at University Kebangsaan Malaysia-Primary Care Centre. Asia Pac Fam Med 2009;8:4–7.
Lawal OO, Rotimi O, Okeke I. Helicobacter pylori in gastroduodenal diseases. J Natil Med Assoc 2007;99:31–4.
Chong VH, Lim KC, Rajendran N. Prevalence of active Helicobacter pylori infection among patients referred for endoscopy in Brunei Darussalam. Singapore Med J 2008;49:42–6.
Tarkhashvili N, Beriashvili R, Chakvetadze N, Moistsrapishvili M, Chokheli M, Sikharulidze M, et al. Helicobacter pylori Infection in Patients Undergoing Upper Endoscopy, Republic of Georgia. Emerg Infect Dis 2009;15:504–5.
Olivares A, Buadze M, Kutubidze T, Lobjanidze M, Labauri L, Kutubidze R, et al. Prevalence of Helicobacter pylori in Georgian patients with dyspepsia. Helicobacter 2006;11:81–5.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.