AUTOIMMUNE HYPOTHYROIDISM IN PATIENT WITH NEUROFIBROMATOSIS-1

Authors

  • Ahmed Faraz Karachi Medical And Dental College/Abbasi Shaheed Hospital
  • Taha Nafees Karachi Medical And Dental College/Abbasi Shaheed Hospital
  • Syed Arsalan Ahmed Karachi Medical And Dental College/Abbasi Shaheed Hospital
  • Shahraiz Shah Rizvi Karachi Medical And Dental College/Abbasi Shaheed Hospital

Abstract

A 53 year old woman, diagnosed with Neurofibromatosis I with multiple neurfibromas over trunk, upper limb & lower limb, she had café au lait spots on her abdomen skin. She was admitted to the tertiary care setup with the complains of cold intolerance, numbness in the limbs, high blood pressure & constipation, patient also had complain of weight gain, lab revealed high TSH, low Free thyroid hormones & positive anti thyroglobulin antibodies. Case was diagnosed with autoimmune hypothyroidism. This is the first case reported with such association of these two diseases.

References

Huson SM, Compston DA, Clark P, Harper PS. A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity. J Med Genet 1989;26(11):704–11.

Viskochil D, Buchberg AM, Xu G, Cawthon RM, Stevens J, Wolff RK, et al. Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell 1990;62(1):187–92.

Nabi J. Neurofibromatosis Type 1 Associated with Hashimoto’s Thyroiditis: Coincidence or Possible Link. Case Rep Neurol Med 2013;2013:910656.

Koksal Y, Sahin M, Koksal H, Esen H, Sen M. Neurofibroma adjacent to the thyroid gland and a thyroid papillary carcinoma in a patient with neurofibromatosis type 1: Report of a case. Surg Today 2009;39(10):884–7.

Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI. et al. Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid 2012;22(12):1200–35.

Downloads

Published

2015-12-16

Most read articles by the same author(s)