MALIGNANT PHYLLODES TUMOUR OF THE BREAST

Authors

  • Farhana Badar
  • Shahid Mahmood
  • Aamir Ali Syed
  • Neelam Siddiqui

Abstract

Background: Malignant Phyllodes Tumour (MPT) is considered to be a rare disease of the breast. Themost frequent clinical presentation of a MPT is a rapidly growing breast lump. Methods: Consecutivecases of MPT registered between Jan 1, 1995 and Dec 31, 2012 at the Shaukat Khanum MemorialCancer Hospital and Research Centre, Lahore, Pakistan, were reviewed, to obtain information on age,tumour size, treatment given, disease-free survival, and overall survival. Disease-free survival wascomputed between the dates of surgery and recurrence, whereas, the overall survival time between thedates of diagnosis and last contact, both in months. Results: A total of 101 cases of Phyllodes tumourwere recorded. These included: malignant tumours (42) benign (27), and borderline (32). MalignantPhyllodes tumours (42 cases) were studied further and 41 included for additional analysis. The meanage of the women in the study was 40.3±12.5 (22–72 years). Of the 33 patients who were disease-freeafter surgery, 15 had a recurrence, whereas, 18 did not have a recurrence. In those who had surgeryalone versus those who received radiation treatment in addition to surgery, the median disease-freesurvival was 117 and 44.2 months, respectively. The mean overall survival time was 33.7 months.Conclusion: In this study, patients presented at a younger age than in other studies. Further explorationinto molecular, biologic, geographic, and socioeconomic factors is needed to clearly understand theepidemiology of this disease in our population.Keywords: Phyllodes tumour, age, recurrence, breast cancer, women, Pakistan

References

Mishra SP, Tiwary SK, Mishra M, Khanna AK. Phyllodes

tumour of breast: a review article. ISRN Surg 2013;1-10.

Soomro SA, Mohammad D, Afridi R, Maher M. Parameters that

influence the prognosis of Phyllodes tumour. Pak J Surg

;23(4):234–6.

NCCN-National Comprehensive Cancer Network-NCCN

Clinical Practice Guidelines in Oncology (NCCN Guidelines)-

Breast Cancer-Version 3.2012.

Shaukat Khanum Memorial Cancer Hospital and Research

Center: Available from: http://www.shaukatkhanum.org.pk/

[cited 2013 May 30].

Guerrero MA, Ballard BR, Grau AM. Malignant phyllodes

tumour of the breast: review of the literature and case report of

stromal overgrowth. Surg Oncol 2003;12(1):27–37.

Johns Hopkins Medicine-Breast cancer. Available from

http://www.hopkinsmedicine.org/avon_foundation_breast_center

/breast_cancers_other_conditions/phyllodes_tumours.html [cited

May 1].

Al-Zoubaidi M, Qiu S, Bonnen M, Joyner M, Roehl K, Silva C,

et al. Malignant Phyllodes Tumour of the Breast: A Case Report.

The Open Breast Cancer Journal 2011;3:45–8.

Damani SR, Perveen S, Shah SSH. Phyllodes tumours of breast:

a review of 30 cases. J Surg Pak 2012;17(3):126–9.

Khatoon S, Arif M, Junejo A, Jamal A, Ahuja P. Clinical pattern

and management outcome of Phyllodes tumour of Breast. J Surg

Pak 2008;13(1):16–8.

Wadood A, Bari A, Qasim KF, Mirza JA, Masud KU. Phylloides

Tumour; report of 7 cases from Quetta and review of literature.

Professional Med J 2006;13(2):324–6.

Khan IR, Shafiq MA, Irshad K, AK Khan, Chaudhry AM.

Recurrent Phyllodes tumour. Ann King Edward Med Uni

;12(2):331–2.

Mahsud ZS, Gul S, Roghani IS. Diagnostic accuracy of

mammography in clinically palpable Breast Lumps. Pak J Radiol

;14(2):5–8.

Khurshid A, Kayani N, Bhurgri Y. Phylloides tumours in

adolescent girls and young women in Pakistan. Asian Pac J

Cancer Prev 2006;7(4):563–6.

Badar F, Moid I, Waheed F, Zaidi A, Naqvi B, Yunus S.

Variables Associated with Recurrence in Breast Cancer Patientsthe Shaukat Khanum Memorial Experience. Asian Pac J Cancer

Prev 2005;6(1):54–7.

Pandey M, Mathew A, Kattoor J, Abraham EK, Mathew BS,

Rajan B, et al. Malignant phyllodes tumour. Breast J

;7(6):411–6.

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Published

2012-12-01

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