• Mujahid -ul- Islam
  • Imtiaz Ahmad
  • Khalid Rafique
  • Rehana Kamal
  • Faahad Abbas


Background: Sympathetic response associated with laryngoscopy and endotracheal intubation isrecognised as a potential cause for a number of complications especially in hypertensive patients.Various methods have been used to attenuate these haemodynamic responses; however most of thestudies are in normotensive patients. The aim of our study was to compare the effect of oral clonidineand I/V fentanyl with oral placebo and I/V fentanyl in attenuating the haemodynamic responses tolaryngoscopy and intubation in known hypertensive patients. Method: In a double blind randomisedcontrolled trial, 60 hypertensive patients, taking antihypertensive drugs and with systolic blood pressurebelow 160 mmHg and diastolic blood pressure below 100 mmHg scheduled for elective surgeries,requiring oral endotracheal intubation and age ranging from 40–65 years were included in this studyand randomly divided into Group A (clonidine 0.2 mg + fentanyl 2 μg/Kg) and Group B (Placebo +fentanyl 2 μg/Kg). Results: Demographic data were comparable in both groups. There were nostatistically significant differences between the two groups in the duration of laryngoscopy andintubation. There was statistically significant attenuation in heart rate in both groups (p=0.020). Thetrends of attenuation of systolic blood pressure, diastolic blood pressure and mean arterial pressure inGroup A compared to Group B, were statistically significant (p=0.034, 0.011, 0.011 respectively).Conclusion: Clonidine, under the present study design attenuates the haemodynamic response tolaryngoscopy and endotracheal intubation in known hypertensive patients.Keywords: Clonidine, haemodynamic response, laryngoscopy, endotracheal intubation, hypertension


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