INCIDENTAL SQUAMOUS CELL CARCINOMA OF THE RENAL PELVIS IN A NONFUNCTIONING KIDNEY THAT WAS MISSED ON TWO NON-CONTRAST CT-SCANS

Authors

  • Masroor Hassan Shifa International Hospital Islamabad
  • Asim Qureshi Shifa International Hospital Islamabad

Abstract

Although the second most common malignancy after urothelial carcinoma, squamous cell carcinoma (SCC) of the renal pelvis is a rare entity. It has strong association with nephrolithiasis thus emphasizing prompt treatment of renal calculi. Because of rarity and nonspecific clinical and radiological findings, it mostly presents at pT3 or higher stage. We report SCC of renal pelvis that was missed two times on non-contrast CT scans and was diagnosed incidentally in a nephrectomy specimen. Its prognosis is similar to that of urothelial carcinoma of comparable stage. Owing to its rarity, no standard treatment guidelines are available, however radical nephrectomy with lymph node dissection is the initial treatment which can be curative in an early stage disease. Adjuvant chemotherapy and radiotherapy are usually ineffective.Keywords:  Squamous cell carcinoma, Imaging, Schistosoma haematobium

Author Biographies

Masroor Hassan, Shifa International Hospital Islamabad

Postgraduate Resident histopathology, Department of Pathology and Laboratory Medicine.

Asim Qureshi, Shifa International Hospital Islamabad

Associate consultant Histopathologist, Department of Pathology and Laboratory Medicine.

References

Kini H, Sridevi HB, Suresh PK, Guni LPG, Bhat S, Kini JR. Spectrum of Lesions Affecting the Renal Pelvis and Pelviureteric Junction: A 13-Year Retrospective Analysis. J Clin Diagn Res 2016;10(2):EC01–4.

Reuter VE. The urothelial tract: Renal pelvis, ureter, urinary bladder and urethra. In: Mills SE, Greenson JK, Hornick JL, Longacre TA, Reuter VE, editors. Sternberg’s Diagnostic Surgical Pathology, 6th ed. Philadelphia: Wolters Kluwer Health; 2015. p.2072.

Bandyopadhyay R, Biswas S, Nag D, Ghosh AK. Squamous cell carcinoma of the renal pelvis presenting as hydronephrosis. J Can Res Ther 2010;6(4):537–9.

Nachiappan M, Litake MM, Paravatraj VG, Sharma N, Narasimhan A. Squamous Cell Carcinoma of the Renal Pelvis, A Rare Site for a Commonly Known Malignancy. J Clin Diagn Res 2016;10(1):PD04–6.

Kalayci OT, Bozdag Z, Sonmezgoz F, Sahin N. Squamous cell carcinoma of the renal pelvis associated with kidney stones: radiologic imaging features with gross and histopathological correlation. J Clin Imaging Sci 2013;3:14.

Mardi K, Kaushal V, Sharma V. Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: Report of two cases. J Cancer Res Ther 2010;6(3):339–41.

Lee TY, Ko SF, Wan YL Cheng YF, Yang BY, Huang DL, et al. Renal squamous cell carcinoma: CT findings and clinical significance. Abdom Imaging 1998;23(2):203–8.

Raghavendran M, Rastogi A, Dubey D, Chaudhary H, Kumar A, Srivastava A, et al. Stones associated renal pelvic malignancies. Indian J Cancer 2003;40(3):108–12.

Jongyotha K, Sriphrapradang C. Squamous Cell Carcinoma of the Renal Pelvis as a Result of Long-Standing Staghorn Calculi. Case Rep Oncol 2015;8(3):399–404.

Bindra R, Gupta S, Gupta N. Cytological diagnosis of squamous cell carcinoma of renal pelvis. J Cytol 2010;27(2):76–7.

Obad-Kovačević D, Kardum-Skelin I, Kaić G, Jelić-Puškarić B, Kovačević K. Hydronephrotic Kidney Previously Treated for Tuberculosis: Rare Primary Squamous Cell Carcinoma of Renal Pelvis Diagnosed by Fine-needle Aspiration Cytology. Urol Case Rep 2015;3(5):173–4.

Jakes A, Jani P, Menon M, Adams K, Edey M, Fleming S, et al. Renal Squamous Cell Carcinoma of a Native Kidney After Renal Transplant: A Case Report. Transplant Proc 2016;48(1):259–61.

Hameed ZB, Pillai SB, Hegde P, Talengala BS. Squamous cell carcinoma of the renal pelvis presenting as sacral bone metastasis. BMJ Case Rep 2014;pii:bcr2013201719.

Al-Assiri M, Al-Otaibi MF, Sircar K, Laplante M. Renal Pelvis Squamous Cell Carcinoma and Renal Cell Carcinoma in a Tuberculous Kidney. Scientific World J 2004;4:965–8.

Sahoo TK, Das SK, Mishra C, Dhal I, Nayak R, Ali I, et al. Squamous cell carcinoma of kidney and its prognosis: a case report and review of the literature. Case Rep Urol 2015;2015:469327.

Berz D, Rizack T, Weitzen S, Mega A, Renzulli J, Colvin G. Survival of patients with squamous cell malignancies of the upper urinary tract. Clin Med Insights Oncol 2012;6:11–8.

Rausch S, Hofmann R, von Knobloch R. Nonbilharzial squamous cell carcinoma and transitional cell carcinoma with squamous differentiation of the lower and upper urinary tract. Urol Ann 2012;4(1):14–8.

Downloads

Published

2017-07-11