PERIPHERAL OSSIFYING FIBROMA OF ORAL CAVITY: HISTOPATHOLOGIC DIFFERENTIAL DIAGNOSES

Authors

  • Thorakkal Shamim

Abstract

Peripheral ossifying fibroma is a benign neoplasm that usually develops from gingiva, presenting as anexophytic smooth surfaced pink or red nodular mass that is sessile or is less frequently seen on apedicle. From the Indian perspective, it is usually noticed in 5th–6th decades of life with femalepredilection. Microscopically, the tumour shows stratified squamous epithelium and highly cellularfibrous stroma, sparse endothelial proliferation with fibroblasts and dystrophic calcifications. It has tobe differentiated histopathologically from pyogenic granuloma, fibroma, peripheral giant cellgranuloma, peripheral odontogenic fibroma and fibrous hyperplasia. A case of peripheral ossifyingfibroma of maxillary gingiva in a 55-year-old Indian woman is reported.Keywords: Peripheral ossifying fibroma, oral cavity, gingival growth, histopathologic differentialdiagnosis

References

Lindhe J, Karring T, Lang NP. Clinical Periodontology and

implant dentistry. 4th ed. Copenhagen: Blackwell Munksgaard;

Moon WJ, Choi SY, Chung EC, Kwon KH, Chae SW.

Peripheral ossifying fibroma in the oral cavity: CT and MR

findings. Dentomaxillofac Radiol 2007; 36(3):180–2.

Shamim T, Varghese VI, Shameena PM, Sudha S. A

retrospective analysis of gingival biopsied lesions in South Indian

population: 2001–2006. Med Oral Patol Oral Cir Bucal 2008;

(7):E414–8.

Gardner DG. The peripheral odontogenic fibroma: an attempt at

clarification. Oral Surg Oral Med Oral Pathol 1982; 54(1):40–8.

Kumar SK, Ram S, Jorgensen MG, Shuler CF, Sedghizadeh PP.

Multicentric peripheral ossifying fibroma. J Oral Sci 2006;

(4):239–43.

Ababneh KT. Biopsied gingival lesions in Northern Jordanians: a

retrospective analysis over 10 years. Int J Periodontics

Restorative Dent 2006; 26(4):387–93.

Poon CK, Kwan PC, Chao SY. Giant peripheral ossifying

fibroma of the maxilla: report of a case. J Oral Maxillofac Surg

; 53(6):695–8.

Bodner L, Dayan D. Growth potential of peripheral ossifying

fibroma. J Clin Periodontol 1987; 14(9):551–4.

Stablein MJ, Silverglade LB. Comparative analysis of biopsy

specimens from gingiva and alveolar mucosa. J Periodontol

; 56(11):671–6.

Kfir Y, Buchner A, Hansen LS. Reactive lesions of the gingiva.

A clinicopathological study of 741 cases. J Periodontol 1980;

(11):655–61.

Buchner A, Hansen LS. The histomorphologic spectrum of

peripheral ossifying fibroma. Oral Surg Oral Med Oral Pathol

; 63(4):452–61.

Prasad S, Reddy SB, Patil SR, Kalburgi NB, Puranik RS.

Peripheral ossifying fibroma and pyogenic granuloma. Are they

interrelated? NY State Dent J 2008; 74(2):50–2.

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Published

2012-12-01