CHANGING HAEMATOLOGICAL PARAMETERS IN DENGUE VIRAL INFECTIONS
AbstractBackground: Dengue Fever is the most common arboviral disease in the world, and presents cyclicallyin tropical and subtropical regions of the world. The four serotypes of dengue virus, 1, 2, 3, and 4, forman antigenic subgroup of the flaviviruses (Group B arboviruses). Transmission to humans of any ofthese serotypes initiates a spectrum of host responses, from in apparent to severe and sometimes lethalinfections. Complete Blood count (CBC) is an important part of the diagnostic workup of patients.Comparison of various finding in CBC including peripheral smear can help the physician in bettermanagement of the patient. Material and Methods: This cross sectional study was carried out on aseries of suspected patients of Dengue viral infection reporting in Ittefaq Hospital (Trust). All wereinvestigated for serological markers of acute infection. Results Out of 341 acute cases 166 (48.7%)were confirmed by IgM against Dengue virus. IgG anti-dengue was used on 200 suspected re-infectedpatients. Seventy-one (39.5%) were positive and 118 (59%) were negative. Among 245 confirmeddengue fever patients 43 (17.6%) were considered having dengue hemorrhagic fever on the basis of laband clinical findings. Raised haematocrit, Leukopenia with relative Lymphocytosis and presenceatypical lymphocytes along with plasmacytoid cells was consistent finding at presentation in both thepatterns of disease, i.e., Dengue Haemorrhagic fever (DHF) and Dengue fever (DF). Conclusion:Changes in relative percentage of cells appear with improvement in the symptoms and recovery fromthe disease. These findings indicate that in the course of the disease, there are major shifts withincellular component of blood.Keywords: Dengue, Complete Blood count, atypical lymphocyte
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