• Amjad Naeem
  • Nadia Nasim
  • Umaira Ihsan
  • Atika Masood


Background: Depolymerisation of acid-mucopolysaccharides results in the loss of metachormasia ofthe ground substance followed by visible fibre crumbling, complete dissolution and replacement bylipid droplets and cholesterol. The objective of this study was to assess the distribution of differentatherosclerotic lesions in celiac, superior mesenteric and inferior mesenteric arteries relation to age andsex. Methods: A prospective descriptive observation study was conducted at Mortuary of King EdwardMedical University Lahore, and Department of Pathology Allama Iqbal Medical College Lahore. Atotal of 30 human autopsies were carried out. Celiac, Superior mesenteric and inferior mesentericarteries were taken out and opened length-wise. One to four areas of tissue were taken from each arteryfor histological examination. Slides were prepared from each paraffin block. Sections were stained withhaematoxylin and eosin. Special stains were performed on sections to display each component ofatherosclerosis. Results: The fibrolipid plaques were seen in 6 cases. The complicated lesions werepresent in 5 cases. Of these, 4 showed ulceration and 1 showed thrombus formation. The calcifiedlesions were observed in 5 cases. The morphological changes in media and elastica were present in 4cases. In superior mesenteric artery fatty streaks were present in 8 cases. The fibrolipid plaques wereconfirmed in 5 cases. Three cases showed ulceration, 1 case showed intimal vascularisation,haemorrhage, and thrombus formation. The calcified lesions were present in 2 cases. Themorphological changes in media and elastica were seen in 4 cases in anterior mesenteric artery. Fattystreaks were present in 8 cases. The fibrolipid plaques were grossly observed in 6 cases. Thecomplicated lesions were present in 4 cases; of these, 3 cases showed ulceration, and 1 showed intimalvascularisation and haemorrhage along with thrombus formation. The calcified lesions were present in3 cases. The morphological changes in media and elastica were present in 4 cases. Conclusion: Thisdata indicates the incidence of ischemic changes in abdominal viscera due to atherosclerotic narrowing.Keywords: Celiac, Superior, Inferior, mesenteric, atherosclerosis, arteries


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