CLINICAL PRESENTATIONS IN IMMUNE THROMBOCYTOPENIC PURPURA
Abstract
Background: Thrombocytopenia is an important cause of mucocutanaeous bleeding in adult andpaediatric patients. Immune thrombocytopenia is one of the common causes of thrombocytopenia. Itsclinical presentations vary from patient to patient, not studied in our area previously. The presentstudy was planned to see the frequency of clinical presentations of Immune ThrombocytopenicPurpura (ITP) in our patients. Methods: This prospective study was conducted on 125 patients withITP, diagnosed by exclusion of secondary causes of thrombocytopenia. Bone marrow examinationwas performed on all the patients. Results: Bruising, epistaxis and gum bleeding were thecommonest clinical presentations in adults and children. Bleeding was more severe in acute cases.Increased menstrual bleeding was seen in female patients. Conclusion: Bruising, epistaxis and gumbleeding are the commonest clinical presentations of ITP. Our results are not much different fromthose of the other studies conducted in Pakistan.Keywords: Thrombocytopenia, Immune thrombocytopenic purpura, mucocutanaeous bleedingReferences
Cines DB, Blanchette VS. Immune thrombocytopenic purpura.
New Engl J Med 2002;346:995–1008.
George JN. Diagnosis, clinical course, and management of
idiopathic thrombocytopenic purpura. Curr Opin Hematol
;3:335–40.
Kuhne T. Idiopathic thrombocytopenic purpura in childhood:
controversies and solutions. Pediatr Blood Cancer
;47(S5):650–2.
McMillan R. Therapy for adults with refractory chronic
immune thrombocytopenic purpura. Ann Intern Med
;126(4):307–14.
Segal J, Powe N. Prevalence of immune thrombocytopenia:
analyses of administrative data. J Thromb Haemost
;4:2377–83.
Muhsen AA, Abdurrahman KN. Bone marrow examination in
isolated childhood thrombocytopenia. Pak Paed J
;35(4):209–12.
Ahmad Z, Naveedur Durrani NR, Hazir T. Bone marrow
examination in ITP in children: is it mandatory? J Coll
Physicians Surg Pak 2007;17:347–9.
Aziz M, Nazar N, Ahmad R, Mazari N, Farooq H, Khan SW,
et al. Clinico hematologic features of immune
thrombocytopenic purpura and its association with autoimmune
disorders. Biomedica 2009;25(1):14–8.
Rehman Z, Alam M, Mubarik A, Ahmed M. Clinical Spectrum
of Thrombocytopenia in Adult Population of Karachi. J Coll
Physicians Surg Pak 2001;11:603–5.
Mohammad J, Rahim F, Nayyar J. Frequency of clinical
features of IdiopathicThrombocytopenic Purpura. J Med Sci
;19 (3):126–8.
Published
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
