SERUM LEVEL OF SOLUBLE INTERLEUKIN-2 RECEPTOR ALPHA AS A PREDICTOR OF TREATMENT RESPONSE IN BRUCELLOSIS
AbstractIntroduction: Iran is one of the endemic regions with high prevalence of brucellosis. Severalserological markers for diagnosis and response to treatment are available. Serum level of SolubleInterleukin-2 Receptor alpha (SIL-2R) is a new marker to assess response to therapy and clinicalrelapse of brucellosis. This study intends to investigate the serum levels of SIL-2R before andafter treatment, to evaluate this marker for patients responding to treatment of brucellosis.Methods: This study is an analytical cross-sectional study. Forty patients who had clinical signs ofbrucellosis and serological tests confirmed the disease have been treated with standard antibioticsfor 6 weeks. 2ME and SIL-2R levels were measured before and after treatment and these valueswere compared. Results: Among the 40 patients, 27 patients (67.5%) had improvement insymptoms and 13 patients (32.5%) had no symptoms after treatment. In Comparing serum levels ofSIL-2R and 2ME before and after treatment, decreasing of both markers after treatment wassignificant (p<0.001). In patients with false positive for 2ME, SIL-2R in 57% of patients had areduction, but in patients with false negative for 2ME, SIL-2R in only 28% of patients increased.Conclusion: Not only is Serum level of SIL-2R useful for predicting response to treatment ofbrucellosis, but also in cases of false positive of 2ME can be helpful.Keywords: Brucellosis, SIL-2R, 2ME
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