FREQUENCY OF HCV INFECTION IN DIFFERENT DERMATOLOGICAL DISORDERS
AbstractBackground: Hepatitis C Virus (HCV) has estimated affected nearly 3% of the world population.Studies in Pakistan have shown a somewhat higher prevalence. The objective of this study was todetermine the frequency of hepatitis C virus infection in patients with dermatological disorders, knownto be associated with HCV infection. Method: This was a descriptive study, conducted at Departmentsof Dermatology, Military Hospital, Rawalpindi and PNS Shifa, Karachi from September 2003 toNovember 2005. There were 355 patients of the dermatologic disorders mentioned above. HCV statuswas determined by the presence of anti-HCV antibodies in the serum, by third generation ELISA.Results: In this study 14% of lichen planus, 8% of generalised pruritus, 7.8% of urticaria, 8.7% ofprurigo, and 50% of porphyria cutanea tarda patients had underlying HCV infection. None of thepatients of leukocytoclastic vasculitis, erythema multiforme or erythema nodosum had anti-HCVantibodies. No patient of mixed cryoglobulinaemia or polyarteritis nodosa was seen during the studyperiod. Conclusions: Patients of lichen planus, generalised pruritus, urticaria, prurigo, and porphyriacutanea tarda have increased frequency of HCV infection compared to normal population of ourcountry. In contrast, none of the patients of leukocytoclastic vasculitis, erythema multiforme orerythema nodosum had HCV infection.Keywords: HCV, cutaneous disorders, lichen planus, porphyria cutanea tarda, urticaria, pruritus,prurigo, erythema multiforme, erythema nodosum
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