• Ayesha Khan Ayub teaching hospital
  • Kashif Rafique Ayub teaching hospital
  • Umer Farooq Ayub teaching hospital
  • Khalid Khan Ayub teaching hospital


Background: Carcinoma breast is most common cancer and the leading cause of cancer related deaths in women, with a multifactorial aetiology. This case control study was aimed at studying the possible link of body fat with the pathogenesis of carcinoma breast. Methods: A case control study extending over a period of two years (2015–2016) was conducted in which the body size and shape of 56 carcinoma breast cases was studied against 168 controls who had no breast disease. Results: Fifty-six women suffering from carcinoma breast had a higher BMI and fat distributed in the abdominal area A high BMI was found to be protective in pre-menopausal women (OR= 0.14 by; 95% CI: 0.02–0.77) while it was a risk factor in post-menopausal women (OR=2.39 by; 95% CI: 1.02–5.55). Waist-to-hip ratio (WHR) of ≥0.9 was associated with an increased risk of carcinoma breast compared to WHR ≤0.8 (OR=3.857 by; 95% CI: 0.875–17.05). Conclusion: the results show there is an increased risk of carcinoma breast in women having more fat cantered around the abdomen.Keywords: postmenopausal; weight gain; fat distribution; fat topography; carcinoma breast; body mass index; body shape; obesity; central obesity

Author Biographies

Ayesha Khan, Ayub teaching hospital

General surgery resident, surgical A unit, Ayub teaching hospital.

Kashif Rafique, Ayub teaching hospital

senior registrar, surgical A unit, Ayub teaching hospital

Umer Farooq, Ayub teaching hospital

Associate professor community medicine, deputy dean Ayub teaching hospital

Khalid Khan, Ayub teaching hospital

professor surgery, head of surgery and allied, Ayub teaching hospital


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