METAPLASTIC SQUAMOUS CELL CARCINOMA IN ASSOCIATION WITH INVASIVE LOBULAR BREAST CARCINOMA WITH METASTASIS TO AXILLARY LYMPH NODES
Abstract
Squamous cell carcinoma (SCC) of the breast is very rare entity and when encountered it is foundin association with invasive ductal carcinoma of the breast. We report a very unusual associationof an invasive lobular carcinoma with metaplastic squamous cell carcinoma of the breast whichwas found not only in a mastectomy specimen but also in the axillary lymph nodes. The patientreported first with a lump breast which was diagnosed a case of invasive lobular carcinoma in alumpectomy specimen, followed by adjunct radiation and chemotherapy. We encountered suchassociation in only one case report in the literature.Keywords: squamous cell carcinoma, lobular carcinoma, Mastectomy, axillary lymph nodesReferences
Sentani K, Tashiro T, Oue N, Yasui W. Synchronous squamous
cell squamous cell carcinoma of the breast and invasive lobular
carcinoma. Ann Pak Inst Med Sci 2007;115:1422–5.
Stevenson JT, Graham DJ, Khiyami A, Mansour EG. Squamous
cell carcinoma of the breast: a clinical approach. Ann Surg Oncol
;3(4):367–74.
Cornog JL, Mobini J, Steiger E, Enterline HT. Squamous cell
carcinoma of the breast. Am J Clin Pathol 1971;55(4):410–7.
Eggers JW, Chesney TM. Chesne Squamous cell carcinoma of
the breast: A clinicopathologic analysis of eight cases and review
of the literature. Hum Pathol 1984;15(6):526–31.
Rosen PP. Rosen’s Breast Pathology 2nd ed. Philadelphia:
Lippincott William & Wilkins; 2001.
Wargotz ES, Deos PH, Norris HJ. Metaplastic carcinoma of the
breast II. Spindle cell carcinoma. Hum Pathol 1989;20(8):732–40.
Kaufman MW, Marti JR, Gallager HS, Hoehn JL. Carcinoma of
the breast with pseudosarcomatous metaplasia. Cancer
;53(9):1908–17.
Healy CF, Feeley L, Leen E, Walsh TN. Primary squamous cell
carcinoma of the breast: value of positron emission tomography
scanning in confirming the diagnosis. Clin Breast Cancer
;7(5):413–5.
Zoltan TB, Konick L, Coleman RJ. Pure squamous cell
carcinoma of the breast in a patient with previous
adenocarcinoma of the breast: a case report and review of the
literature. Am Surg 2001;67(7):671–3.
Siegelmann-Danieli N, Murphy TJ, Meschter SC, Stein ME,
Prichard J. Primary pure squamous cell carcinoma of the breast.
Clin Breast Cancer 2005;6(3):270–2.
Li Z, Li YT. Squamous cell carcinoma of the breast. Am J Surg
;147(5):701–2.
