PATTERN OF DYSLIPIDEMIA IN ADULT DIABETIC SUBJECTS IN THE COMMUNITY HOSPITAL OF DISTRICT SWAT

Authors

  • Sahibzada Saeed Jan
  • Taj Muhammad Khan
  • Rashid Ahmad
  • Safeer Zaman
  • Aziz Ahmad

Abstract

Background: The incidence of diabetes is growing at dramatic rates around the word and itscomplications are associated with significant health and financial burdens, warranting strong andcomprehensive prevention efforts. The objective of the present study was to evaluate the pattern ofdyslipidemia in the adult diabetic patients in Saidu Teaching Hospital, Saidu Sharif, Swat.Methods: The study comprised of 100 subjects, 50 subjects with diabetes and 50 (non-diabetic)controls. The serum Cholesterol, Triglycerides, High-density Lipoprotein-Cholesterol (HDL-C)and Low-density Lipoprotein-Cholesterol (LDL-C), blood sugar (random and fasting), bloodpressure (systolic and diastolic) of Diabetic subjects were compared with Control subjects.Results: Diabetic subjects had high mean value of Triglycerides and LDL-C (but statistically nonsignificant), low level of HDL-C (statistically highly significant) and high blood pressure ascompared to Control subjects. Conclusion: Dyslipidemia is a potent predictor of cardiovascularmorbidity and mortality in diabetic patients.Keywords: Diabetes mellitus, Dyslipidemia, Blood pressure

References

Riccardi G, Aggett P, Brighenti F, Delzenne N, Frayn K,

Nieuwenhuizen A, et al. Body weight regulation, insulin

sensitivity and diabetic risk. Eur J Nutr 2004;43(suppl 2):ii7–ii46.

Meier JJ. Beta cell mass in diabetes. Diabetologia

;51:703–13.

Stookey DJ, Pieper FC, Cohen JH. Hypertonic hyperglycemia

progresses to diabetes faster than normotonic hyperglycemia. Eur

J Epidemiol 2004;19:935–44.

Kasai T, Miyauchi K, Kajimoto K, Kubota N, Kurata T, Daida H.

Influence of diabetes on >10 years outcomes after percutaneous

coronary intervention. Heart Vessels 2008;23:149–54.

Maret W. Zinc and diabetes. Bio Metals 2005;18:293–4.

Frier B, Yang P, Taylor WA. Diabetes, aging and physical

activity. Eur Rev Aging Phys Act 2006;3::63–73.

Bottle A, Millet C, Khunti K, Majeed A. Trends in cardiovascular

admissions and procedure for people with and without diabetes in

England, 1996–2005. Diabetologia 2009;52:74–80.

Schule BM, Shai I, Manson EJ, Li T, Rifai N, Jiang R, et al. Joint

role of Non-HDL cholesterol and glycated hemoglobin in

predicting future coronary heart disease events among women

with type-2 diabetes. Diabetologia 2004;47:2129–36.

Kengne PA, Patel A, Barzi F, Jamrozik K, Lam HT, Ueshima T,

et al. Cholesterol, diabetes and major cardiovascular diseases in

the Asia-Pacific region. Diabetologia 2007;50:2289–97.

Codario RA. Diabetic dyslipidemia, In: Type-2 diabetes, prediabetes and the metabolic syndrome: The primary guide to

diagnosis management. Totowa NJ: Humana Press Inc; 2005.p.

–70.

Bittner V, Hardison R, Kelsey FS, Weiner HB, Jacobs KA,

Sopko G. Non-high-density lipoprotein cholesterol levels predict

five-years outcome in the bypass angioplasty revascularization

investigation. Circulation 2002;106:2537–42.

Ansorge R. Lowering high triglycerides, cholesterol is very

important in diabetes. 2008. Available at:

http://cholesterol.about.com/lw/Health-Medicine/Conditionsand-diseases/Cholesterol-Triglycerides-and-Diabetes.-1PT.htm

Lee J, Reding M. Effects of thiazolidinediones on stroke

recovery; a case-matched controlled study, Neurochem Res

;32:635–8.

Lemieux I, Lamarche B, Couillard C, Pascot A, Cantia B,

Bergeron J, et al. Total cholesterol/HDL cholesterol ratio vs LDL

cholesterol/HDL cholesterol ratio as indices of ischemic heart

disease risk in men (The Quebec cardiovascular study). Arch

Intern Med 2001;161:2685–92.

Toth PP. The good cholesterol high-density lipoprotein,

Circulation 2005;111:e89–e91.

J Ayub Med Coll Abbottabad 2011;23(1)

http://www.ayubmed.edu.pk/JAMC/23-1/Saeed.pdf 109

Kengne PA, Patel A, Barzi F, Jamrozik K, Lam HT, Ueshima T,

et al. Cholesterol, diabetes and major cardiovascular diseases in

the Asia-Pacific region. Diabetologia 2007;50:2289–97.

Moroney TJ, Tang XM, Berglund L. Low-density lipoprotein

cholesterol and the risk of dementia with stroke. JAMA

;282;254–60.

Farmer AJ. Diabetic dyslipidemia and atherosclerosis: evidence

from clinical trials. Curr Diab Rep 2008;8(1):71–7.

Fontbonne A, Eschwège E, Cambien F, Richard JL, Ducimetière

P, Thibult N, et al. Hypertriglyceridaemia as a risk factor of

coronary heart disease mortality in subjects with impaired

glucose tolerance or diabetes. Results from the 11-year follow-up

of the Paris Prospective Study. Diabetologia 1989;32:300–4.

Yeo KK, Tai CB, Heng D, Lee MJJ, Ma S, Hughes K, et al.

Ethnicity modifies the association between diabetes mellitus and

ischemic heart disease in Chinese, Malays and Asian Indians

living in Singapore. Diabetologia 2006;49:2866–73.

Downloads

Published

2011-03-01