• Abdul Rashid Surahio
  • Ashar Ahmad Khan
  • Main Usman Farooq
  • Iffat Fatima


Background: Infection is a great problem in surgery and is encountered by all surgeons by nature oftheir craft; they invariably impair the first line of host defence. Bacteria may enter the wound during orafter the operation and may be of endogenous or exogenous origin. The objective of this study was todetermine the effectiveness of preoperative antibiotic prophylaxis in reduction of postoperative woundinfection in clean and clean contaminated procedures and to compare the cost of antibiotic prophylaxisin both groups. Method: This was a prospective study done on patients in General SurgeryDepartment, Al-Noor Specialist Hospital, Holly Makkah, Saudi Arabia from 1st April 2006 to 30thMarch 2007. Total 400 patients were divided into 2 groups of 200 patients each: Group-A receivedsingle dose antibiotic prophylaxis, and Group-B received 3 doses of antibiotic therapy. Only clean andclean contaminated procedures were included and results were compared. Results: In Group A, cleanprocedures (Group-A1) were 110, and clean contaminated (Group-A2) were 90 patients. In cleanprocedure, rate of infection was 5 out of 110 (4.54%) and in clean contaminated procedures it was 3 outof 90 (3.33%). In Group B, in clean procedures (Group-B1), rate of infection was 7 out of 90 (7.77%),while in clean contaminated procedures (Group-B2) it was 9 out of 110 (8.18%) patients. Over allwound infection rate after single dose antibiotic prophylaxis was 4% in both procedures and 8% after 3-dose antibiotic therapy. Conclusion: Single dose antibiotic prophylaxis is as effective as 3-dosetherapy in clean and clean contaminated procedures to prevent wound infection and is cost-effective.Keywords: Surgical wound, Infection, Antibiotic prophylaxis, Clean, Clean contaminated procedure


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