ELEMENTS REGULATION DURING CARTILAGE AND BONE DEFORMITY - POTENTIAL CLINICAL INDEX IN EARLY DIAGNOSIS, MONITORING AND PROGNOSIS IN CHILDREN OF KASHIN-BECK DISEASE
AbstractBackground: Kashin-Beck Disease (KBD) is a chronic deforming osteoarthritis starting in early childhood and affecting the cartilage metabolism and endochondral ossification. Selenium (Se) deficiency has been postulated as the major environmental etiological factor for KBD by many studies. Other minerals such as the Manganese (Mn) and calcium (Ca) which don’t have uniform distribution in environment are also important elements involved in bone and cartilage formation but their regulation in KBD has been rarely reported. The study was done to investigate the role ofMn and Ca in addition to Se in KBD. Methods: In this study, the Se, Mn and Calevels were investigated in children from different groups (KBD group, Healthy group from KBD endemic areas (inner control group), Healthy group (outer control group) from Non KBD areas and KBD group with selenium supplementation). The contents of Mn, S and Ca in serum and hair were analyzed by inductively coupled plasma mass spectrometry. Results: The increased Mnlevels of serum and hair in KBD children were observed compared with normal groups. The Mn and Ca have similar trends in different groups but Se and Mn displayed reversed trends. Conclusions: The Mn and Ca contributed to KBD pathogenesis combined with se in regulation of growth and development. The relative ratio of Mn to Se can be a potential clinical index in early diagnosis, monitoring and prognosis of KBD in children.
Public health annual review in China. 10-5-2. National Health and Family Planning Commission of China. [Internet] [Cited 2015 Mar 7] Available from: http://www.nhfpc.gov.cn/htmlfiles/zwgkzt/ptjnj/year2013/
Tan J, Zhu W, Wang W, Li R, Hou S, Wang D, et al. Selenium in soil and endemic diseases in China. Sci Total Environ 2002;284:227–35.
Mo DX. Pathology of selenium deficiency in Kashin-Beck disease.in: Combs GF, Spallholz JE, Levander OA, Oldfield JE. eds. Selenium in Biology and Medicine. A V I Publishing Company, New York; 1987:859–986.
Guo X, Zhang SY, Mo DX. A Role of low selenium in the occurrence of Kashin-Beck Disease. J Xi’an JiaotongUniv Med Sci1992;4:99–108.
Wang HY, Chen Z.The paired study on the relationship between KBD and Selenium in hair. Chin J Ctrl Endem Dis 2008;23:59–60.
Michaël D, Philippe M, Françoise M, Philippe G, Shancy R, Georges L.Kashin-Beck disease: evaluation of mineral intake in young Tibetan children from endemic areas. Scientific congresses and symposiums. Life sciences: Food science. [Internet] [Cited 2015 Mar 7] Available at: http://hdl.handle.net/2268/85213. 2010.
Sun GJ, Xiong CHL, Zhang Y, Wang SHK, Xie Y, Wang H, et al. Comparative analysis of the inorganic elements in wheats collected from Kashin-Beck Disease (KBD) area and non KBD area. Stud Trace Elem Heal 2004;21:23–25.
Levander OA.Etiological hypotheses concerning Kashin Beck disease, AIN symposium proceedings,American Institute of Nutrition Annual Meeting, Washington DC, 1987:67–71.
Voshchenko AV, Ivanov VN. Kashin-Beck disease in the USSR. Kashin-Beck disease and non-communicable disease. World Health Organization, CAPM, Beijing;1990:152–96.
Aleksintzeva NN. Eco-geochemical features of the south-eastern Transbaikalia region, endemic due to Kashin-Beck disease. Abstract of thesis, Minsk 1987,20.
Zamana LV. Possible hydrogeochemical preconditions for Kashin-Beck disease in transbaikalia. Chin Geo Sci 1995;5:185–92.
Diagnosis of Kaschin-Beck disease (WS/T 207-2010). National Health and Family Planning Commission of China. [Internet] [Cited 2015 Feb 28] Available from: http://www.nhfpc.gov.cn/zwgkzt/s9500/201006/47920.shtml.2010.
Ma WJ, Guo X, Liu JT,Liu RY, Hu JW, Sun AG, et al. Proteomic changes in articular cartilage of human endemic osteoarthritis in China. Proteomics 2011;11(14):2881–90.
Mizoguchi N, Nishimura Y, Ono H, Sakura N.Manganese elevations in blood of children with congenital portosystemic shunts. Eur J Pediatr2001;160(4):247–50.
Spencer A.Whole blood manganese levels in pregnancy and the neonate. Nutrition 1999;15(10):731–4.
Rodrigo-Reyes R, Egrise D, Nève J, Pasteels JL, Schoutens A. Selenium deficiency-induced growth retardation is associated with an impaired bone metabolism and osteopenia. J Bone Miner Res 2001;16(8):1556–63.
Rollin, R., Tornero, P., Marco, F., Camafeita, E., Calvo, E., Lopez-Duran, L, et al. Differential proteome of articular chondrocytes from patients with osteoarthritis. J Proteomics Bioinform 2008;1(5):267–80.
Leach RM Jr, Muenster AM, Wien EM. Studies on the role of manganese in bone formation. II. Effect upon chondroitin sulfate synthesis in chick epiphyseal cartilage. Arch Biochem Biophys 1969;133(1):22–8.
Leffler CT, Philippi AF, Leffler SG, Mosure JC, Kim PD. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind,placebo-controlled pilot study. Mil Mid 1999;164(2):85–91.
Das A, Hammad TA. Efficacy of combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate, and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage 2000;8(5):343–50.
Cao J, Li S, Shi Z, Yue Y, Sun J, Chen J, et al. Articular cartilage metabolism in patients with Kashin-Beck Disease: an endemic osteoarthropathy in China. Osteoarthritis Cartiage 2008;16(6):680–8.
Guo X, Thomas A, Pirkko L. [A study on abnormal chondrocyte differentiation and abnormal expression of collagen types in articular cartilage from patients with Kaschin-Beck disease]. Zhonghua Bing Li Xue Za Zhi 1998;27(1):19–22.
Xiaoyan M, Li SC, Zhang ShY, Yan TJ. Study on disaccharides and components of glycosaminoglycan in urine from children with Kashin-Beck disease. Chin J Ctrl Endem Dis 1994;9:197–9.
Gao Z, Guo X, Duan C, Ma W, Xu P, Liu R, et al. In vitro effects of sodium hyaluronate on the proliferation and the apoptosis in chondrocytes from patients with Kashin-Beck disease and osteoarthritis. J Nanjing Med Uni 2009;23(2):104–10.
Abe M, Takahashi M, Nagano A.The effect of hyaluronic acid with different molecular weights on collagen crosslink synthesis in cultured chondrocytes embedded in collagen gels. J Biomed Mater Res A 2005;75(2):494–9.
Li SCH, Mo XY, Zhang SHY, Yu ZHD, Li YCh. Investigation on the relationship between urinary selenium and urinary excretion of hydroxyproline and glycosaminoglycan in children with Kashin-Beck disease. Endem Dis Bul 1992;7:73–76.
Xu YCh, Zhang ShY, Bai C, Yu ZhD. The effect of selenium and sulphur on collagen metabolism rate in the children with Kashin Beck’s disease. Chin J Endemiol 1988;7:152–4.
Bai C, LvShM, Wang ZhL, Xue L. Analysis of serum Cu, Zn, Mn, Fe contents of the children from Kashin-Beck disease affected areas. Chin J Ctrl Endem Dis 1994;9(2):71–2.
Yan C, Junmin D, Zhilun W, Xiwang T, Li Z, Dong G.A comparative research on the treatment effect of Se supplement, Vit C supplement and cereals dryness on Kaschin-Beck disease. Chin J Ctrl Endem Dis 2003;6:343–6.
Guo X, Zhang ShY, Yin PP. The elements changes in Kashin-Beck Disease prevention under the comprehensive intervention and spray selenium on wheat. Chin J Ctrl Endem Dis 1989;4(3):151–3.
Marlovits S, Hombauer M, Truppe M, Vècsei V, Schlegel W.Changes in the ratio of type-I and type-II collagen expression during monolayer culture of human chondrocytes. J Bone Joint Surg Br 2004;86(2):286–95.
Ryan MC, Sandell LJ. Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA. J Biol Chem 1990;265(18):10334–9.
Downey CM, Horton CR, Carlson BA,b Parsons TE, Hatfield DL, Hallgrímsson B, et al. Osteo-chondroprogenitor–specific deletion of the selenocysteinet RNA gene, trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for kashin-beck disease. PLoS Genet 2009;5(8):e1000616.
Darden AG, Ries WL, Wolf WC, Rodriguiz RM, Key LL Jr. Osteoclastic superoxide production and bone resorption: stimulation and inhibition by modulators of NADPH oxidase. J Bone Miner Res 1996;11(5):671–5.
Allen RG, Keogh BP, Gerhard GS, Pignolo R, Horton J, Cristofalo VJ. Expression and regulation of superoxide dismutase activity in human skin fibroblasts from donors of different ages. J Cell Physiol 1995;165(3):576–87.
Balin AK, Pratt L, Allen RG. Effects of ambient oxygen concentration on the growth and antioxidant defenses of human cell cultures established from fetal and postnatal skin. Free Radic Biol Med 2002;32(3):257–67.
Allen RG, Newton RK, Sohal RS, Shipley GL, Nations C. Alterations in superoxide dismutase, glutathione, and peroxides in the plasmodial slime mold Physarumpolycephalum during differentiation. J Cell Physiol 1985;125(3):413–9.
Stewart MS, Spallholz JE, Neldner KH, Pence BC. Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis. Free RadicBiol Med 1999;26(1-2):42–8.
Behne D, Kyriakopoulos A. Mammalian selenium-containing proteins. Annu Rev Nutr 2001;21:453–73.
Jin M, Lu GL, Lei ShY. A correlative study on trace element selenium and the bioactive substances in children with Kaschin-Beck disease. Chin J Ctrl Endem Dis 2004;19:135–8.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.