• Zehra Naz
  • Saadia Anjum


Background: With advancing age the chances of benign prostatic hyperplasia (BPH) and carcinomaprostate (CaP) increases. Although previous studies on physical parameters and personal dataparameters have shown the positive associations between BMI, family history, and marital status butthey have not seen the effect of occupation and socioeconomic status on BPH and CaP. Theobjective of the present study was to see the effects of anthropometric measurements and personalhistory parameters on BPH and CaP in our community. Methods: Ninety-three willing subjects fromthe outpatient department of Sindh Institute of Urology and Transplant (SIUT) were selected for thestudy. Height and weight were measured, BMI calculated and personal data information, i.e.,occupation, marital status, smoking history, family history and socioeconomic history were recorded.Data were analysed for association of various parameters with BPH and CaP. Results: Significantassociation between weight, BMI and skilled labourers was found when normal were compared withBPH cases. Conclusion: No significant association between other parameters and BPH, CaP caseswas found, except weight, BMI and skilled labour. Body weight should be managed well as it canlead to both cardiovascular as well as prostatic diseases.Keywords: Body mass index, Benign Prostatic Hyperplasia, CaP, Carcinoma prostate


Arrighi HM, Metter EJ, Guess HA, Fozzard JL. Natural history

of benign prostatic hyperplasia and the risk prostectomy: The

Baltimore longitudinal study of aging. Urology 1991;38(1


Lee F, Littrup PJ, Loft-Christensen L, Kelly BS, McHugh

TA, Siders DB, et al. Predicted prostate specific results using

transrectal ultrasound gland volume. Differentiation of

benign prostatic hyperplasia and prostate cancer. Cancer

;70(1 Suppl):211–20.

Kuriyama M, Wang MC, Papsidero LD, Killian CS, Shimano T,

Valenzeula L, et al. Quantitation of prostate specific antigen in

serum by a sensitive enzyme immunoassay. Cancer Res


McConnell JD, Prostatic growth-new insights into hormonal

regulation. Br J Urol 1995;76:5–10.

Bostwick DG, Shan A, Qian J, Darson M, Maihle NJ, Jenkins

RB, et al. Independent origin of multiple foci of prostatic intraepithelial neoplasia. Cancer 1992;83:1995–2002.

Zahir N, Mubarik A, Abdullah P, Mehmood A, Zahur-ur

Rehman. Pattern of malignant tumors in Karachi, is it different? J

Coll Phys Surg Pak 2000;10:338–41.

Abbas F, Scardino PT. The natural history of prostate carcinoma.

Cancer 1997;80:827–33.

Freeland SJ, Sutter ME, Naitoh J, Dorey F, Csathy GS, Aroson

WJ. Clinical characteristics in black and white men with

prostate cancer in an equal access medical center. Urology


Kalish LA, McDougal WS, McKinlay JB. Family history and the

risk of prostate cancer. Urology 2000;56:803–6.

Arruda HO, Vieira-Filho JP, Ortiz V, Srougi M. PSA and

anthropometric measurements among Amazon Indians: an

evaluation of the Parkateje community. Rev Saude Publica


Irani J, Lefebvre O, Murat F, Dahmani L, Dore B. Obesity in

relation to prostate cancer risk: comparison with a population

having benign prostatic hyperplasia. BJU Int 2003;91:482–4.

Freeland SJ, Platz EA. Obesity and prostate cancer: Making

sense out of apparently conflicting data. Epidemiol Rev


J Ayub Med Coll Abbottabad 2010;22(3)

http://www.ayubmed.edu.pk/JAMC/PAST/22-3/Zehra.pdf 57

Wernyl DM, Thompson T, Saraiyal M, Freedman D, Kottiri BJ,

German RR, et al. obesity is negatively associated with prostate

specific antigen in US men, 2001–2004. Cancer Epidemiol

Biomarkers Prev 2007;16(1):70–6.

Rundle A, Neugut AI. Obesity and screening of PSA levels

among men undergoing an annual physical examination. Prostate


Price MM, Hamilton RJ, Robertson CN, Butts MC, Freeland SJ.

Body mass index, prostate specific antigen and digital rectal

examination findings among participants in a prostate cancer

screening clinic. Urology 2008;71:787–91.

Mills PK, Beeson WL, Phillips RL, Fraser GE. Cohort study of

diet, life style and prostate cancer in Adventist men. Cancer


Weinrich MC, Jacobsen SJ, Weinrich SP, Moul JW, Oesterling

JE, Jacobson D, et al. Reference ranges for serum prostate

specific antigen in black and white men without cancer. Urology

;52: 967–73.

Mills PK, Yang R. Prostate cancer risk in California farm

workers. J Occup Environ Med 2003;45:249–58.

Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J,

Koskenvuo M, et al. Environmental and heritable factors in the

causation of cancer. Analyses of cohorts of twins from Sweden,

Denmark and Finland. N Engl J Med 2000;343:78–85.

Catalona WJ, Antenor JA, Roehl KA, Moul JW. Screening for

prostate cancer in high risk population. J Urol 2002;168:1980–3.

Johns LE, Houlston RS. A systematic review and meta-analysis

of familial prostate cancer risk. BJU Int 2003;91:789–94.