EFFECTS OF ‘OLEA EUROPEA’ EXTRACT ON VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION, LIVER AND KIDNEY FUNCTION IN RABBITS
AbstractBackground: Peptic ulcer is mostly produced due to the over production of gastric acid. This study wasundertaken to find out the effects of extract from the leaves of medicinal plant Olea europea (whichcontains documented natural Calcium channel blocker) on volume and acidity of Carbachol inducedgastric section. Its effects were also observed on liver and kidney function. Methods: Thirty rabbits oflocal breed, weighing 1–1.5 kg were used. The animals were kept on fasting for 48 hours, after that thepylorus of each animal was ligated. Carbachol 600 μg/kg body weight and extract from the leaves ofOlea europea 500 mg/kg body weight were administered intraperitoneally to group A and Brespectively. The extract was also administered in the same dose to group C for 45 days twice dailyintraperitoneally to observe its effects on liver and kidney function. Results: The extract reduced thevolume, free and total acidity of gastric secretion, which were statistically highly significant whencompared with Carbachol (p<0.001). When the differences of means for both the liver and kidneyfunction were compared with that of control group, all these were found statistically non-significantindicating that the extract has no adverse effects on these organs regarding all parameters included instudy. Conclusion: Extract can be used effectively and safely in the treatment of hyper gastric acidityconditions and peptic ulcer after evaluation of its effects in human subjects.Keywords: Medical plants, Olea Europea
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