ROLE OF ANTI-THROMBOTIC THERAPY FOR RECURRENT PREGNANCY LOSS DUE TO ANTI-PHOSPHOLIPID SYNDROME
AbstractBackground: Recurrent pregnancy loss is a major health problem effecting 1‒2% of women ofreproductive age. Its causes range from chromosomal abnormalities to endocrinological factors andthrombophilia related factors. Treating thrombophilias especially antiphospholipid syndrome with lowdose aspirin and low molecular weight heparin improves foetal outcome. This study will add local datato already existing knowledge. Method: Sixty selected patients from gynaecology OPD of AeroHospital with clinical and/or serological findings of antiphospholipid syndrome from February 2009 toJanuary 2011 were given aspirin 75 mg once daily and enoxaparine 40 mg subcutaneously once dailyfrom 6–8 weeks to 35 and 37 weeks respectively. Results: Ninety-three percent of patients achievedlive birth. Out of these 75% patients delivered at term and 18% had preterm delivered. Four (7%) hadearly pregnancy loss and only one had early neonatal death due to extreme prematurity. None ofpatients experienced any major hemorrhagic complications. Conclusion: Use of low dose aspirin andlow molecular weight heparin is safe in pregnancy and improve foetal outcome in patients withrecurrent pregnancy loss due to antiphospholipids syndrome.Keywords: Recurrent pregnancy loss, Antiphospholipid syndrome, low molecular weight heparin
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