PROGNOSTIC AND THERAPEUTIC ROLE OF NUCLEAR FACTORkappa B (NF-κB) IN BREAST CANCER
AbstractNuclear Factor- kappa B (NF-κB) is an essential transcription factor that not only modulates cellularresponses to stress but also plays a pivotal role in inflammation, immunity, cell cycle growth andsurvival. NF-κB-regulated genes have been documented to be involved in cellular proliferation andinvasion along with tumour related angiogenesis and lymphangiogenesis. Dysregulation of NF-κBassociated pathways are seen in multiple malignancies. Its constitutive activation in the clinicallyaggressive and prognostically poor ER-negative, Her2-neu positive and inflammatory breast cancercould formulate the basis for its evolution as a potential prognostic and therapeutic target.Keywords: Nuclear Factor kappa B, NF-κB, Breast Cancer, ER-negative
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