MINIMAL CHANGE DISEASE, THE LEADING CAUSE OF GLOMERULOPATHIES IN PAEDIATRIC POPULATION AT PESHAWAR
AbstractBackground: Glomerulonephritis (GN) is a relatively rare disease with numerous subtypes. Mostregional nephrology centres see only a limitednumber of patients with each type of GN every year. Theobjective of this study was to find out the pattern of glomerulopathies in paediatric population,undergoing renal biopsy in Peshawar. Methods: This was a prospective study carried out at theDepartment of Nephrology, Khyber Teaching Hospital, Peshawar from May 2002 to May 2004.Ultrasound guided percutanous renal biopsies were carried out in patients with the findings of: 1)Nephrotic range proteinuria in children, 2) Non-nephrotic range proteinuria with evidence ofhypertension/haematuria/deranged renal function or active sediments on urine microscopy, 3) Steroidresistant nephrotic syndrome in children, and 4) Children with nephrotic syndrome who were nottolerant of steroid therapy or were considered for immunosuppressive drugs. Results: A total of 155renal biopsies were taken. Out of these 90 were male patients and 65 were female. The most commonhistopathological lesion among children population was Minimal Change Disease (42.66%) followedby Focal Segmental Glomerulosclerosis (25.33%) and Membranous Glomerulonephritis (16.0%).Nephrotic range proteinuria was most prevalent in Minimal Change Disease and MembranousGlomerulonephritis followed by Focal Segmental Glomerulosclerosis. Non-nephrotic range proteinuriawas mostly seen in patients with Membranoprolifirative Glomerulonephritis. Conclusion: In paediatricpopulation, Minimal Change Disease is the most commonly encountered glomerulopathy, followed byFocal Segmental Glomerulosclerosis and Membranous Glomerulonephritis.Keywords: Nephrotic Syndrome, Renal biopsy, Proteinuria, Glomerulopathy
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