• Muhammad Ejaz Ahmed
  • Iftikhar Ahmad
  • Saleem Akhtar


Background: Breast screening is a method of detecting breast cancer at a very early stage. Most of thelesions detected by screening are not malignant. Objective of this study was to compare ultrasoundguided fine needle aspiration cytology and core biopsy in the preoperative assessment of non-palpablebreast lesions. Methods: The study was conducted prospectively at Department of Radiology, ShaukatKhanum Memorial Cancer Hospital and Research Centre, Pakistan from March 2004 to February 2005.All the patients underwent fine needle aspiration cytology and core biopsy. Later on, all of them hadexcision biopsy/ mastectomy. Prospectively 80 patients were studied; information was collected on aspecifically designed form according to inclusion criteria. The patient age, sex, medical record numberand side of lesion were recorded. Clinical history of duration of lump was also taken. Informed consentwas obtained. Results: The age of patients were ranges from 20–71 years, with mean of 44.31±11.002and the maximum number of patients 28 (35.3%) was between the ages 50–59 years. The sensitivity ofFNAC was 92.85%, while the specificity of was 90% and the accuracy rate was 92.1%. The sensitivityof core biopsy was 94.64%, specificity 91.30% and accuracy rate was 94.87%. Conclusion: FineNeedle Aspiration has been found to be an extremely useful method for the diagnosis of lumps ofbreast. The accuracy and the sensitivity of diagnosis on fine needle aspiration cytology were high.Keywords: fine needle biopsy, core biopsy, ultrasound guided, non-palpable breast cancer, breast lesion


Silverstein MJ, Gamagami P, Colburn WJ, Gierson

ED, Rosser RJ, Handel N, et al. Nonpalpable breast

lesions: diagnosis with slightly overpenetrated screen-film

mammography and hook wire-directed biopsy in 1014 cases.

Radiology 1989;171:633–8.

Alexander HR, Candela FC, Dershaw DD, Kinne DW.

Needle-localized mammographic lesions: results and

evolving treatment strategy. Arch Surg 1990;125:1441–4.

Layfield LJ, Parkinson B, Wong J, Giuliani AE, Basset LW.

Mammographically guided fine-needle aspiration biopsy of

nonpalpable breast lesions Can it replace open biopsy?

Cancer 1991;68:2007–11.

Thompson WR, Bowen JR, Dorman BA, Pricolo VE,

Shahinian TK, Soderberg CH. Mammographic localization

and biopsy of nonpalpable breast lesions. Arch Surg


Fajardo LL, Pisano ED, Caudry DJ, Gatsonis CA, Berg

WA, Connolly J, et al. Stereotactic and sonographic largecore biopsy of nonpalpable breast lesions. Acad Radiol


Apestegu´a L, Pina L, Inchusta M, Mellado M, Franquet

T, De Miguel C, et al. Nonpalpable, well-defined, probably

benign breast nodule: management by fine-needle aspiration

biopsy and long-interval follow-up mammography. Eur

Radiol 1997;7:1235–9.

Thurfjell E. Mammographically-guided fine needle aspiration

in differential diagnosis of cystic versus solid rounded

masses smaller than 2 cm detected at mammographic

screening. Breast Cancer Res Treat 2002;75:221–6.

Frable WJ. Thin needle aspiration biopsy. Philadelphia: WB

Saunders Co; 1983. p.1–71.

Pennes DR, Naylor B, Rebner M. Fine needle aspiration

biopsy of the breast. Influence of the number of passes and

the sample size on the diagnostic yield. Acta Cytologica


Bibbo M. Scheiber M, Cajulis R, Keebler CM, Wied

GL, Dowlatshahi K. Stereotaxic fine needle aspiration

cytology of clinically occult malignant and premalignant

breast lesions. Acta Cytol 1988;32:193–201.

Das DK, Sodhani P, Kashyap V, Parkash S, Pant

JN, Bhatnagar P. Inflammatory Lesions of the Breast:

Diagnosis by Fine Needle Aspiration. Cytopathology


Dejmek A, Lindholm K. Frequency of Cytologic features in

fine needle aspirates from histologically and cytologically

diagnosed fibroadenomas. Acta Cytol 1991;35:695–9.

Bottles K, Chan JS, Holly EA, Chiu SH, Miller TR.

Cytology criteria for fibroadenoma: A step-wise logistic

regression analysis. Am J Clin Pathol 1988;89:707–9.

Bright RA, Morrison AS, Brisson J. Burstein

NA, Sadowsky NL, Kopans DB, et al. Histologic and

mammographic specificity of risk factors for benign breast

disease. Cancer 1989;64:653–7.

Garre Sánchez MC, Sola Pérez J, Bas Bernal

A, Mercader Martínez J, López Alanis A. Ultrasound

guided fine needle aspiration biopsy. Study of the cost per

patient and comparison with computed tomograpgy guided

biopsy. Rev ESP Enferm Diag 1997;89:297–304.

Collacol M, deLima RS, Werner B, Torres IFB. Value of fine

needle aspiration in the diag of breast lesions. Acta Cyto


Alderson MR, Hamlin I, Staunton MD. The relative

significance of prognostic factors in breast carcinomas. Br J

Cancer 1971;25:646–56.

J Ayub Med Coll Abbottabad 2010;22(2)


Howat AJ, Hoda RS. Correspondence. Why pathologists

should take needle aspiration specimens. Cytopathology


Wells CA, Ellis I. O, Zakhour HD, Wilson AR. Cytology

subgroup of the national coordinating committee for breast

cancer screening pathology. Guidelines for cytology

procedures and reporting of fine needle aspirates of the

breast. Cytopathology 1994;5;316–34.

Abele AS, Miller TR, Goodson WH 3rd, Hunt TK, Hohn

DC. Fine needle aspiration of palpable breast masses: A

Program for staged implementation. Arch Surg


Rimm DL, Stastny J, Rimm EB, Ayer S, Frable WJ.

Comparison of the costs of fine needle aspiration and open

surgical biopsy as methods for obtaining a pathological

diagnosis. Cancer 1997;81:51–6.

Adye B, Jolly PC, Bauermeister DE. The role of fine-needle

aspiration in the management of solid breast masses. Arch

Surg 1988;123:37–9.

Dixon JM, Clarke PJ, Crucioli Vl. Dehn TC, Lee

EC, Greenall MJ. Reduction of the surgical excision rate in

bening breast disease using fine needle aspiration cytology

with immediate reporting. Br J Surg 1987;74:1014–6.

Quershi N, Usman N. Comparison of fine needle aspiration

cytology with histology in palpable breast lesions. Biomedica


Bodó M, Döbrössy L, Sugár I, Boeck’s sarcoidosis of the

Breast: Cytologic findings with aspiration biopsy cytology: a

case clinically mimicking carcinoma: Acta Cytol 1978;22:1–2.

National Health System Breast Screening program.

Guidelines for cytology procedures and reporting in breast

cancer screening. Sheffield: NHSBSP publication; 1993.

Hirst C, Davis N. Core biopsy for microcalcification in the

breast. Aust N Z J Surg 1997;67:320–4.

Schimazu K, Masana N, Yamada T, Okamoto K, Kanda K.

Cytologic evaluation of phylloides tumour as compared to

fiberadenoma of breast. Acta Cytol 1994;38:891–7.

Lifrange E, Kaidelka F, Collin C. Stereotaxic needle-core

biopsy and fine-needle aspiration biopsy in the diagnosis of

nonpalpable breast lesions: controversies and future

prospects. Eur J Radiol 1997;24:39–47.




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