CORRELATION BETWEEN PLASMA THYROID HORMONES AND LIVER ENZYMES LEVEL IN THYROTOXIC CASES AND CONTROLS IN HAZARA DIVISION
AbstractBackground: Thyrotoxicosis is defined as increased synthesis and secretion of thyroid hormones;when associated with defused goitre it is known as grave’s disease. Hepatic changes in thyrotoxiosis arefatty changes, cirrhosis and centrilobular necrosis, resulting in elevated serum levels of liver specificenzymes ALT, AST and ALK. Objective of the study was to determine a correlation between plasmalevels of 3 liver enzymes, and thyroid hormones in thyrotoxic cases, and matched controls in HazaraDivision. Methods: This study was conducted at Ayub Teaching Hospital Abbottabad from 1st July2004 to 30th June 2007. The controls were selected from staff and students of Ayub Medial CollegeAbbottabad. Fifty cases of thyrotoxicosis and 50 controls were included in this study by conveniencesampling. Their thyroid profile for T3, T4, TSH and liver enzymes profile for ALT, AST, ALK weredetermined and analysed for a correlation. Results: Mean T3 of cases was 5.23±1.95 and of controls1.95±0.35. Mean T4 of case was 248.88±62.75, and of controls was 113.40±19.01. Mean TSH of caseswas 0.07±0.25 and that of controls was 2.24±0.80. Mean ALT of cases was 38.78±4.96 while that ofcontrols was 23.98±5.27. Mean AST of cases was 39.76±5.05 and of controls was 26.52±4.49. MeanALK of cases was 299.68±22.32 and of controls was 155.10±37.07. Conclusion: Although liverenzymes levels were slightly elevated in many thyrotoxic cases, no significant correlation emergedbetween any of the thyroid hormones and any of the liver enzymes, either in cases or controls.Keywords: Thyrotoxiosis, Liver enzymes, Grave’s disease, Hyperthyroidism
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