• Talat Ahmed
  • Halima Sadia
  • Sadia Batool
  • Ayesha Janjua
  • Faiza Shuja


Background: Fruits and vegetables are shown to reduce blood pressure. It is not merely theantioxidants contained in fruits and vegetables that have health benefits such as lowered systolicand diastolic blood pressures. This study was undertaken to see the cardiovascular protectiveeffects of prunes. Methods: A placebo controlled clinical trial study was designed to see theeffects of Prunus domestica on blood pressure in 259 pre-hypertensive (Systolic BP=120–139mmHg, diastolic BP=80–89 mmHg) volunteers. Treated groups drank prune juice and ate thewhole fruit (dried plums) while either 3 (about 11.5 gm) or 6 prunes were soaked overnight in aglass of water whereas control group took only a glass of plain water early in the morning onempty stomach. Blood pressure was recorded fortnightly for 8 weeks, and blood samples weretaken at 0 and 8 weeks. Results: There was significant reduction of blood pressure by single doseof prunes daily group and the controls (p<0.05). With the double dose of prunes, only systolic BPwas reduced significantly (p<0.05). Control group had significantly increased serum HDLwhereas test groups had significantly reduced serum cholesterol and LDL (p<0.05). Data wasanalysed by paired-sample t-test with 95% confidence interval. Conclusion: The data predictscardiovascular protective effects of prunes.Keywords: Plums, Prunus domestica, blood pressure, lipid profile, pre-hypertensive patients


Ness AR, Powles JW. Fruit and vegetables, and cardiovascular

disease: a review. Int J Epidemiol 1997;26:1–13.

John,J, Ziebland S, Yudkin P, Roe LS, Neil HA. Effects of fruit and

vegetable consumption on plasma antioxidant concentrations and

blood pressure: a randomized controlled trial.

Lancet 2002;359:1969–74.

Guidelines subcommittee. 1999 World Health Organization–

International society of hypertension guidelines for the management

of hypertension. J Hypertension 1999;17:151–83.

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA,

Izzo JL, et al. The seventh report of the joint national committee on

prevention, detection, evaluation, and treatment of high blood

pressure. JAMA 2003;289:2560–71.

Nadkarni, AK. Indian Materia Medica, originally edited by late

Nadkarni KM revised and enlarged by Nadkarni AK. 3rd Ed.

Bombay: 1950. p1014–5.

Mosby’s Medical Dictionary, 2002.

Eguchi,S, Frank, G, Utsunomiya, H. Popular Japanese plum, now

available in the US, may help prevent the onset of cardiac disease.

American Physiological Society 2003. available at:

Terpstra AHM, Lapre JA, de Vries HT, Beynen AC. Dietary Pectin

with High Viscosity Lowers Plasma and Liver cholesterol

concentration and plasma cholesteryl ester transfer protein activity in

hamsters. J Nutr 1998;128:1944–9.

Dikeman CL, Bauer LL, Fahey GC Jr. Carbohydrate composition of

selected plum/prune preparations. J Agric Food Chem


Tinker LF, Davis PA, Schneeman BO. Prune fiber or pectin

compared with cellulose lowers plasma and liver lipids in rats with

diet-induced hyperlipidemia. J Nutr 1994;124(1):31–40.

Tinker LF, Schneeman BO, Davis PA, Gallaher DG, Waggoner

CR. Consumption of Prunes as a Source of Dietary Fiber in

Men with Mild Hypercholesterolemia. Am J Clin Nutr


Chuda Y, Ono H, Ohnishi-Kameyama M, Matsumoto K, Nagata T,

Kikuchi Y. Mumefural, citric acid derivative improving blood

fluidity from fruit-juice concentrate of Japanese apricot (Prunus

mume Sieb. et Zucc). J Agric Food Chem 1999;47:828–31.

Utsunomiya H, Takekoshi S, Gato N, Utatsu H, Motley ED, Eguchi

K, et al. Fruit-juice concentrate of Asian plum inhibits growth signals

of vascular smooth muscle cells induced by angiotensin II. Life Sci


Rhian M. Touyz Reactive Oxygen Species, Vascular Oxidative

Stress, And Redox Signaling In Hypertension, what is the clinical

significance? Hypertension 2004;44:248–52.

Ceriello A, Diabetes Complications and Hypertension-Novel Insights

into Pathophysiology and Management, Original Article: Possible

Role of Oxidative Stress in the Pathogenesis of Hypertension.

Diabetes Care 2008;31:S181–S184.

Kayano S, Kikuzaki H, Yamada NF, Aoki A, Kasamatsu K,

Yamasaki Y, et al. Antioxidant properties of prunes (Prunus

domestica L.) and their constituents. Biofactors 2004;21(1-4):309–

Kayano S, Kikuzaki H, Ikami T, Suzuki T, Mitani T, Nakatani N. A

new bipyrrole and some phenolic constituents in prunes (Prunus

domestica L.) and their oxygen radical absorbance capacity (ORAC).

Biosci Biotechnol Biochem 2004;68(4):942–4.

Kikuzaki H, Kayano S, Fukutsuka N, Aoki A, Kasamatsu K,

Yamasaki Y, et al. Abscisic acid related compounds and

lignans in prunes (Prunus domestica L.) and their oxygen

radical absorbance capacity (ORAC). J Agric Food Chem


Kayano S, Yamada NF, Suzuki T, Ikami T, Shioaki K,

Kikuzaki H, et al. Quantitative evaluation of antioxidant

components in prunes (Prunus domesticaL.). J Agric Food

Chem 2003;51:1480–5.

Bellentani S, Bedogni G, Tiribelli C. Liver and heart: A new link? -

ALT Predicts Heart Disease. J Hepatol 2008;49(2):300–2.




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