• Samina Zaman
  • Sarosh Majid
  • Mahvish Hussain
  • Omer Chughtai
  • Javed Mahboob
  • Sohail Chughtai


Background: Ovaries are common site of non-neoplastic and neoplastic lesions. They can presentfrom the neonatal period to post menopause. Most are functional in nature and resolve with minimaltreatment. Objective of the study was to determine the nature of various ovarian lesions and to ascertainthe frequency and distribution of the various non-neoplastic and neoplastic lesions. Methods: Thestudy was a retrospective review of all cases of ovarian cancer, benign ovarian neoplasm and functionalovarian cysts received during Jan–Dec 2008 at Chughtai’s Lahore Laboratory. The clinical data of thepatients was obtained from their respective files. Results: A total of 498 different non-neoplastic andneoplastic lesions were seen during one calendar year 2008. Non-neoplastic cysts were more common(343, 68.87%) than neoplastic tumours (155, 31.12%). The commonest non-neoplastic cyst was lutealcyst followed by follicular cyst. Among the neoplastic tumours 78.70% were benign and 21.29% weremalignant. Benign serous cysts were the commonest benign tumour followed by mature cystic teratomaand mucinous cyst. Serous cystadenocarcinoma was the commonest malignant tumour followed closelyby endometrioid carcinoma and granulosa cell tumour. Krukenberg tumour, tumour metastatic toovaries and non-Hodgkins lymphoma was also diagnosed during this period. Malignant germ celltumours were seen in much younger age group followed by sex cord stromal tumours. Epithelialtumours were seen in much older age group. Conclusion: The morphologic diversity of ovarian massesposes many challenges. A specific diagnosis can usually be made by evaluating routinely stained slidesbut sometimes immunohistochemistry is required in difficult cases. Gross features also provide usefuldiagnostic clues.Keywords: Ovarian functional cysts, ovary, ovarian neoplasm


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