RISK FACTORS OF URINARY BLADDER CANCER IN PESHAWAR REGION OF KHYBER PUKHTOONKHAWA
AbstractBackground: Urinary Bladder cancer is a fatal disease. No work about its risk factors has beenconducted in northern Pakistan. This case control study was conducted in order to investigatethe risk factors of the urinary bladder cancer in that area. Method: For this study 150 subjectsincluding 50 cases and 100 controls were interviewed from the 2 tertiary care hospitals ofPeshawar and the information was collected about the characteristics like gender, age, smokinghabits, family history of cancer, etc. Descriptive and inferential statistics were used to explainthe risk factors of the disease. Odds ratios and 95% Confidence Intervals were computed byusing logistic regression model. Results: The odds ratio and 95% confidence interval forchemical exposure are 4.637 and (1.022–21.053), for cigarette smoking 19.526 and (4.688–81.329), for lifestyle 0.171 and (0.031–0.943), for fluid consumption 0.025 and (0.005–0.115),for fried items 5.934 and (1.429–24.648), and for fruits are 0.173 (0.045–0.660), respectively.Conclusions: Chemical exposure, cigarette smoking, and high use of fried items increase therisk of urinary bladder cancer. Moderate lifestyle, high fluid consumption and use of fruits areprotective against the disease.Keywords: Bladder cancer, Controls, Odds ratio, Questionnaire, Risk factors
Steward BW, Kleinhaus P. World Cancer Report: WHO-Lyon:
Lousbergh D, Broeders G, Cloes E, Dhollander D, Thijs G, Op de
Beeck A, et al. Incidence of cancer in the Belgian province of
Limburg 1996-2001. (LIKAS vzw, Ed.). Hasselt: Diepenbeek
Visser O, Coeberg J, Dijck van J, Siesling S. Incidence of cancer in
the Netherlands 1998. Utrecht: Association of comprehensive cancer
Schottenfeld D, Fraumeni JF. Cancer Epidemiology and Prevention.
New York, Oxford: Oxford University Press: 1996.
Boring CC, Squires TS, Tong T, Montgomery S. Cancer Statistics.
Ca Cancer J Clin 1994;44(1):7–26.
Sylvester RJ, Oosterlinck W, Meijden AP. A single immediate
postoperative instillation of chemotherapy decreases the risk of
recurrence in patients with stage Ta, T1 bladder cancer: a metaanalysis of published results of randomized clinical trials. J Urol.
Pirastu R, Iavarone I, Comba P. Bladder cancer: a selected review of
the epidemiologic literature. Ann Ist Super Sanita. 1996;32:3–20.
Burch JD, Rohan TE, Howe GR. Risk of bladder cancer by source
and type of tobacco exposure: A case control study. Int. J Cancer
Clavel J, Cordier S, Boccon GL, Hemon D. Tobacco and bladder
cancer in males: Increased risk of in halers and smokers of black
tobacco. Int J Cancer 1989;44:605–10.
Morrison AS. Advances in the etiology of urothelial cancer. Urol
Clin North Am 1984;11:557–66.
Augustine A, Herbert JR, Kabat GC, Wynder ER. Bladder cancer in
relation to cigarette smoking. Cancer Res 1988;38:4405–8.
Pelucchi C, Vecchia LC, Negri E, DalMaso L, Franceschi, S.
Smoking and other risk factors for bladder cancer in women. Prev
Mommsen S, Aagaard J, Sell A. An epidemiological study of
bladder cancer in a predominantly rural district. Scand J Urol
Villanueva CM, Cantor KP, King WD, Jaakkola JJ, Cordier S,
Lynch CF, et al. Total and specific fluid consumption as
determinants of bladder cancer risk. Int J Cancer. 2006; 118:2040–7.
Zeegers MP, Kellen E, Buntinx F, van den Brandt PA. The
association between smoking, beverage consumption, diet and
bladder cancer: a systematic literature review. World J Urol
Bianchi GD, Cerhan JR, Parker AS, Putnam SD, See WA, Lynch
CF, et al. Tea consumption and risk of bladder and kidney cancers in
a population-based case-control study. Am J Epidemiol
Zeegers MP, Dorant E, Goldbohm RA, van den Brandt PA. Are
coffee, tea, and total fluid consumption associated with bladder
cancer risk? Results from the Netherlands Cohort Study. Cancer
Causes Control 2001;12:231–8.
Claus EB, Schildkraut JM, Thompson WE, Risch NJ. The genetic
attributable risk of breast and ovarian cancer. Int J Cancer
Riboli E, Gonzales CA, Lopez-Abente G, Errezola M, Izarzugaza I,
Escolar A, et al. Diet and bladder cancer in Spain: a multi-centre
case-control study. Int J Cancer 1991;49:214–9.
Hebert JR, Miller DR. A Cross-national Investigation of diet and
bladder cancer. Eur J Cancer 1994;30:778–84.
Bruemmer B, White E, Vaughan TL, Cheney CL. Nutrient intake in
relation to bladder cancer among middle-aged men and women. Am
J Epidemiol 1996;144:485–95.
Radosavljevic´ V, Jankovic´ S, Marinkovic´ J, Dokic´ M. Diet and
bladder cancer: A case-control study. Int Urol Nephrol.
Negri E and Vecchia CL. Epidemiology and prevention of bladder
cancer. Euro J Cancer Prev 2001;10:7–14.
Hosmer DW and Lomeshow S. Applied Logistic Regression. New
York: John Wiley and Sons, Inc; 1989.
Kogevinas M, Mannetje A, Cordier S, Ranft U, Gonzalez CA,
Vineis P, et al. Occupation and bladder cancer among men in
Western Europe. Cancer Causes Control. 2003;14:907–14.
Kogevinas M, Garcia-Closas M, Trichopoulos D. Urinary bladder
cancer. In: A Text book of Cancer Epidemiology. Oxford University
Silverman DT, Morrison AS and Devesa SS. Bladder cancer. In:
Schottenfeld D, Fraumeni JF, eds. Cancer Epidemiology and
Prevention, New York: Oxford University Press; 1996.p. 1156–79.
Brennan P, Bogillot O, Greiser E, Chang-Claude J, Wahrendorf J,
Cordier S, et al. The Contribution of Cigarette Smoking to Bladder
Cancer in Women (Pooled European Data) Source: Cancer Causes
Samanic C, Kogevinas M, Dosemeci M, , Malats N, Real FX,
Garcia-Closas M, et al. Smoking and bladder cancer in Spain: effects
of tobacco type, timing, environmental tobacco smoke, and gender.
Cancer Epidemiol Biomarkers Prev 2006;15:1348–54.