OBESITY, HYPERLIPIDEMIA, AND HYPERURAECEMIA IN YOUNG AND OLD HYPERTENSIVE PATIENTS
AbstractBackground: There is strong correlation among hypertension, obesity, hyperlipidemia andhyperuricemia which are important risk factor for the cardiovascular disease. Objective of this studywas to assess and compare the prevalence of obesity, hyperlipidemia and hyperuricemia amongyoung and old hypertensive patients in the local setting. Methods: This cross-sectional study wasconducted at medical Out-patient Department at Shahina Jamil Teaching Hospital, Abbottabad, fromSeptember 2007 to February 2008. Eighty-six patients seen in the medical outpatient departmentwere enrolled in the study. Patients with age 15 years or above and diagnosed as case of systemichypertension were included. Patients with endocrine disease, pregnancy, coarctation of aorta, andrenal disease leading to hypertension were excluded from the study. Results: Total eighty-sixpatients with mean age of 53.7±12.9 years were included in the study. Patients were divided intoyounger age group (age <46 years) and older age group (age ≥46 years). Mean Body Mass Index(BMI) was 29.7±5.2 in the younger age group and 26.9±4.7 in the older age group, mean serumcholesterol level was 192.2±14.2 mg/dL in younger age group and 190.9±18.3 mg/dL in the olderage group, mean serum triglyceride level was 170.5±13.7 mg/dL in younger age group and166.6±21.4 mg/dL in the older age group and mean serum uric acid levels were 5.6±0.7 mg/dL inyounger age group and 5.7±1.2 mg/dL in the older age group. Overweight and obese patients were70.9% with its higher prevalence in younger (86.2%) as compared to older patients (63.2%).Hypercholesterolemia was found in 27.9% of the patients, with a frequency of 24.1% in youngerpatients and 29.8% in the older patients. Hypertriglyceridemia was seen in 66.3% of the patients,with a frequency of 69.0% in younger patients and 64.9% in the older patients. Hyperuricemia waspresent in 37.2% of the hypertensive patients with a frequency of 34.5% in the younger patients and38.6% in the older patients. Conclusion: Hypercholesterolemia, hypertriglyceridemia, andhyperuricemia are not associated with the age of the hypertensive patients. Increased BMI is morefrequent in the young as compared to the old hypertensive patients.Keywords: hypertension, obesity, hypercholesterolemia, hypertriglyceridemia, hyperuricemia
Jousilahti P, Tuomilehto J, Vartiainen E, Valle T, Nissinen A.
Body mass index, blood pressure, diabetes and risk of antihypertensive drug treatment: 12 years follow-up of middle-aged
people in eastern finland. J Hum Hypertens 1995;9:847–54.
Rana TF, Mahmood S, Ahmad M, Akhtar RM. Assessment of
Body Mass index (BMI) in medical students (a cross sectional
Survey) Ann King Edward Med Coll 2006;12:545–6.
Jones DW, Kim JS, Andrew ME, Kim SJ, Hong YP. Body mass
index and blood pressure in Korean men and women: the Korean
National Blood Pressure Survey. J Hypertens 1994;12:1433–7.
Doll S, Paccaud F, Bovet P, Burnier M, Wietlisbach V. Body
mass index, abdominal adiposity and blood pressure: consistency
of their association across developing and developed countries.
Int J Obes Relat Metab Disord 2002;26:48–57.
Dyer AR, Liu K, Walsh M, Kiefe C, Jacobs DR Jr, Bild DE.
Ten-year incidence of elevated blood pressure and its predictors:
the CARDIA Study Coronary Artery Risk Development in
(Young) Adults. J Hum Hypertens 1999;13:13–21.
Juhaeri Stevens J, Chambless LE, Tyroler HA, Rosamond W,
Nieto FJ, Schreiner P, et al. Associations between weight gain
and incident hypertension in a bi-ethnic cohort: the
Atherosclerosis Risk in Communities Study. Int J Obes Relat
Metab Disord 2002;26:58–64.
Miller ER, Erlinger TP, Young DR, Jehn M, Charleston J,
Rhodes D, et al. Results of the Diet, Exercise, and Weight Loss
Intervention Trial (DEW-IT). Hypertension 2002;40:612–8.
Masuo K, Mikami H, Ogihara T, Tuck ML. Weight gain-induced
blood pressure elevation. Hypertension 2000;35:1135–40.
Huang Z, Willett W, Manson J, Rosner B, Stampfer M, Speizer
F. Body weight, weight change, and risk for hypertension in
women. Ann Intern Med 1998;128:81–8.
Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz
WH. The disease burden associated with overweight and obesity.
J Ayub Med Coll Abbottabad 2009;21(4)
Zhang X, Sun Z, Zheng L, Li J, Liu S, and Xu C. Prevalence of
dyslipidemia and associated factors among the hypertensive rural
Chinese population. Arch Med Res 2007;8:432–9.
Zhang X, Patel A, Horibe H, Wu Z, Barzi F, Rodgers A, et al.
Cholesterol, coronary heart disease, and stroke in the Asia Pacific
region. Int J Epidemiol 2003;32:563–72.
Jafar TH, Chaturvedi N, Pappas G, Prevalence of overweight and
obesity and their association with hypertension and diabetes
mellitus in an Indo-Asian population. CMAJ 2006;175:1071–7.
National Heart, Lung and Blood Institute. Report of the expert
panel on detection evaluation and treatment of high blood
cholesterol adult. National cholesterol education programme.
Washington DC, US Department of Health and Human Services,
Executive summary of the Third Report of the National
Cholesterol Education Programme (NECP) Expert Panel on
Detection, Evaluation, and Treatment of High Blood Cholesterol
in Adult (Adult Treatment Panel III). JAMA. 2001;285:2486–97.
Ezeanyika LUS, Ugwu CE, Nwanguma BC, Onah LE, Ojobo C,
Abba V. Assessment of cardiovascular disease risk factors of an
urban Nigerian hypertensive population using a risk score
calculator. Pak J Med Sci 2008;24:390–94.
Burchfiel CM, Abbott RD, Sharp DS, Curb JD, Rodriguez BL,
Yano K. Distribution and correlates of lipids and lipoproteins in
elderly Japanese-American men. The Honolulu Heart Program.
Arterioscler Thromb Vasc Biol 1996;16:1356–64.
Baloch AA, Siddiqui S, Tariq H, Hamid SY, Shaikh Z
Hypertension and obesity. Med Channel 2008;14:22–4.
Brown CD, Higgins M, Donato K A, Rohde FC, Garrison R,
Obarzanek E. Body mass index and the prevalence of
hypertension and Dyslipidemia. ObesRes 2000;8:605–19.
Shaikh MA, Qazi RA. Hypercholesterolemia in hypertensive
patients. Ann Pak Inst Med Sci 2005;1:142–5.
Sattar RA, Ahmed S, Hussain S, Irtiaz Rizvi SM, Ara J.
Frequency of lipid abnormalities in essential hypertension. J Surg
Rehman A, Sattar A, Abaidullah S, Hassan M. Evaluation of
Cardiovascular Risk Factors in Patients with Essential
Hypertension. Ann King Edward Med Coll 1999;5:134–7.