SEROPREVALENCE OF HEPATITIS C IN PREGNANT FEMALES OF HAZARA DIVISION

Authors

  • Nasreen Gul
  • Javed Sarwar
  • Muhammad Idris
  • Jamila Farid
  • Farhat Rizvi
  • Muhammad Suleman
  • Syed Humayun Shah

Abstract

Background: Hepatitis C Virus (HCV), the causative agent of Hepatitis C is prevalent in differentcountries including Pakistan. Studies have been conducted on various aspects of HCV in Pakistan.The present study was planed to see the prevalence of hepatitis C in pregnant females of HazaraDivision. Methods: Five hundred pregnant females of reproductive age group from HazaraDivision selected by non probability convenient sampling technique were studied from 1st March2006 to 28th February 2007 at Ayub Teaching Hospital, and District Headquarter HospitalsAbbottabad, Haripur and Mansehra. After initial serving by immunology technique positive caseswere confirmed by Enzyme Linked Immunosorbant Essay (ELISA). Results: Seroprevalence ofHCV in pregnant females of Hazara division was 8.9%. Females aged from 25–35 constituted thelargest group among positive cases. HCV was more prevalent in District Abbottabad as comparedto the other districts of Hazara division. Conclusion: Seroprevalence of HCV in pregnant femalesof Hazara Division is different from the figures already reported form the other parts of Pakistan.Keywords: Hepatitis C, Chronic liver disease, Seroprevalence

References

Hayes PC, Simpson KJ, Garden OJ. Liver and biliary tract

Disease. In: Haslett C, Chilvers ER, Boon NA, Colledge NR.

(eds). Davidson’s Principles and Practice of Medicine 19thed.

Edinburgh: Churchill Livingstone;2002. p.831–88.

Burroughs AK, Westaby D. Liver, biliary and pancreatic diseases.

In: Kumar P, Clark M. (eds). Clinical Medicine 5th ed. London: WB

Saunders; 2002. p.335–404.

Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton

M. Isolation of a cDNA clone derived from a blood borne non-A

non–B viral hepatitis genome. Science 1989;244:359–62.

Alter MJ, Kniszon–Moran D, Nainan OV, McQuilian GM, Gao P,

Moyer DA, et al. The prevalence of hepatitis C virus infection in the

United States 1988 through 1994. N Engl J Med 1999;341:556–62.

WHO. (2000). Hepatitis C – global prevalence (update). Wkly

Epidemiol Rec 2000; 75:18–9.

Roggendorf M, Meisel H, Viazov S. Natural history of hepatitis

C. J Virol 2000;95(Suppl-1):189–92.

Schreiber GB, Busch MP, Kleinman SH, Korlitz JJ. The risk of

transfusions transmitted viral infections. N Engl J Med

;334:1685–90.

Roberts, EA, Yeung L. Maternal–infant transmission of hepatitis

C virus infection. Hepatology 2000;36:S106–S113.

Terrault NA. Sexual activity as a risk factor for hepatitis C.

Hepatology 2002;36:S99–S105.

Di Bisceglie AM. Natural history of hepatitis C , its impact on

clinical management. Hepatology 2000;31:1014–8.

Strader DB, Wright T. Global Burden of Disease for hepatitis C.

J Clin Pharmacol 2004;44:20–9.

Shepard CW, Finelli L, Fiore AE, Bell BP. Epidemiology of

hepatitis B and hepatitis C virus infection in United States.

Children. Pediatr Infert Dis J 2005;24:755–60.

Frank C, Mohammed MK, Strickland GT, Layanchy D, Arthur

RR, Magdard S, et al. The role of parenteral antischistosomal

therapy in spread of hepatitis C virus in Egypt. Lancet

;355:887–91.

Perz JF, Anstrong GL, Farrington LA, Hutin Y, Bell BP. The

contributions of hepatitis B virus and hepatitis C virus infections

to cirrhosis and primary liver cancer world wide. J.Hepatol

;45:529–38.

Alter MJ, Hutin YJ, Amstrong GL. Epidemiology of hepatitis C.

In: Liang TJ, Hoofnagle JH. Eds. Hepatitis C. San Diego CA:

Academic press; 2000.p. 169–83.

Nakano NI, Eto A, Chikaura Y, Oishi TM. Multienzyme control

serum (seraclear-HE) containing human enzymes from

established cell lines and other sources. 2: Evaluation as

candidate working enzymes reference material for Alanine and

Aspartate Aminotransferases. J Clin Chem Clin Biochem

;24:497–510.

Desois D,Vaghefi P, Savarg J, Dubsaix E, Roque-Afonso AM.

Sensitivity of a rapid immunochromatographic test for hepatitis C

antibodies detection. J Clin Virol 2008;41(2):129–33.

Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert

WL, Alter MJ. The prevalence of hepatitis C virus infection in

the United States, 1999 through 2002. Ann Intern Med

;144:705-14.

Yousafanii S, Mumtaz F, Memon A, Memon MA, Sikandar R.

Antenatal screening for hepatitis B & C virus carrier state at a

University Hospital. J Liaquat Uni Med Health Sci

;5(1):24–7.

Mohammad J, Hussain M, Khan MA. Frequency of hepatitis B

and hepatitis C infection in thalassaemic children. Pak Pediatr J

;27(4):161–4.

Ali N, Khattak J, Anwar M, Tariq WZ, Nadeem M, Irfan M, et

al. Prevalence of hepatitis B surface antigen & hepatitis C

antibodies in young healthy adults. Pak J Pathol 2002;13(4):3–6.

Aziz MS. Prevelence of antihepatitis C antibodies and hepatitis B

surface antigen in healthy blood donors in Baltistan. Pak Armed

Forces Med J 2006;56(2):189–91.

Mirza IA, Mirza SH, Irfan S, Siddiqui R, Tariq WZ, Jangua AN.

Seroprevalence of hepatitis B and C in young adults seeking

recruitment in armed forces. Pak Armed Forces Med J

;56(2):192–7.

Farooq MA, Iqbal MA, Tariq WZ, Hussain HB, Ghani I.

Prevalence of hepatitis B & C in healthy cohort, Pak J Pathol

;16(2):42–6.

Talpur AA, Anorri AG, Awan NA, Grumro AA. Surgical

patients. Pak J Surg 2006;22(3):150–3.

Ahmed N, Tanwani Ak. Prevelence of hepatitis B surface antigen

and anti hepatitis C virus anti bodies in laboratory based data at

Islamabad. J Surg 2000;19–20:25–9.

Shah MA, Khan MT, Ullah Z, Ashfaq Y. Prevalence of hepatitis

B and hepatitis C virus infection in multi transfused thalassaemia

major patients in north western frontier province. Pak Med Sci

;21(3):281–3.

Zaidi A, Tariq WZ, Haider KA, Ali A, Sattar A, Faqeer F, et al.

Seroprevalence of hepatitis B, C and HIV in healthy blood

donors in North west of Pakistan. Pak J Pathol 2004;15(1):11–6.

Mahmood MA, Khawar S, Anjum AH, Ahmad SM, Rafiq IN,

Usman M. Prevalence of hepatitis B,C and HIV infection in blood

donors of Multan region. Ann King Edward Med 2004;10:459–61.

Khokar N, Gill ML, Malik GJ. General seroprevalence of

hepatitis B and hepatitis C virus infection in population. J Coll

Physicians Surg Pak 2004;14:534–6.

Ashraf MN, Hussain T. Prevalence of Hepatitis B and C in

diabetics. Pak J Pathol 2004;15(3):113–5.

Published

2009-12-01

Most read articles by the same author(s)

<< < 1 2 3 4 5 > >>