SERUM ADIPONECTIN LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE

Authors

  • Iram Fayyaz
  • M. Zamir Ahmed
  • Syed Imran Shah
  • Sadia Mehmood
  • Shama Akram
  • Mansoor Ghani

Abstract

Background: Adiponectin is an adipocytokine secreted from white adipose tissue. Serum level ofadiponectin has been shown to be reduced in several disease states like obesity and diabetes.Hypoadiponectinemia has also been included in the list of newer risk factors for Coronary ArteryDisease (CAD). Methods: In this analytical cross-sectional study serum adiponectin level wasmeasured by Enzyme Linked Immunosorbant Assay (ELISA) in 60 cases of coronary arterydisease (CAD) (both sexes, aged 40–60 yrs) and 60 healthy controls. Results: Low levels ofadiponectin were seen in CAD patients as well as controls. These levels were lower as comparedto western standards. Conclusion: Our study conforms to the previous observation of lower serumadiponectin levels in South Asians compared to the western standards. Serum adiponectin levelshould be considered in the laboratory work-up of CAD patients.Keywords: Coronary Artery Disease (CAD), adiponectin, hypoadiponectinemia, adipocytokine,Enzyme Linked Immunosorbant Assay (ELISA)

References

Scherrer PE, Williams S, Fogliano M, Baldini G, Lodish HF A

novel serum protein similar to c1q produced exclusively in

adipocytes. J Biol Chem 1995;270:26746–9.

Hu E, Liang P, Spiegelman. AdipoQ is a novel adipose-specific

gene dysregulated in obesity. J Biol Chem 1996;271:10697–703.

Maeda K, Okubo K, Schimomura L, Funahashi T, Matsuzawa Y,

Matsubara K. cDNA cloning and expression of a novel adipose

tissue collagen like factor , apM1 (adipose most abundant gene

transcript 1). Biochem Biophys Res Commun 1996;221:286–9.

Nakano Y, Tobe T, Choi-Mura NH, Mazda T, Tomita M.

Isolation and characterization of GBP28, a novel gelatin–

binding protein purified from human plasma. J Biochem

;120:803–12.

Gil-Campos M, Canete R, Gil A. Adiponectin, the missing link

in insulin resistance and obesity. Clin Nutr 2004;23:963–74.

Hopkins TA, Ouchi N, Shibata R, Walsh K. Adiponectin actions

in the cardiovascular system. Cardiovasc Res 2007;74:11–8.

Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and

disease. Diabetes Obes Metab 2007;9:282–9

Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, O

Yoshihisha, et al. Plasma concenteration of a novel adipose

specific protein, adiponectin, in type 2 diabetic patients.

Arteriscler Thromb Vasc Biol 2000;20:1595–9.

Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm

EB. Plasma adiponectin levels and risk of myocardial infarction

in men. JAMA 2004;291:1730–7.

Retnakaran R., Hanley A, Zinman B. Does hypoadiponectinemia

explain the increased risk of diabetes and cardiovascular disease

in South Asians? Diabetes Care 2006;29:1950–4.

Vishwanathan M, Deepa R, Deepa R, Vimaleswaran KS, Mohan

A, Velmurugan K et al. Association of low adiponectin levels

with the metabolic syndrome—the Chennai Urban Rural

Epidemiology Study (CURES-4). Metabolism 2004;54: 476–8.

Valsamakis G, Chetty R., McTernan PG, Al-Daghri NM,

Barnett AH, Kumar S. Fasting serum adiponectin concentration

is reduced in Indo-Asian subjects and is related to HDL

cholesterol. Diabetes Obes Metab 2003;5:131–5.

Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S,

Ouchi N, et al. Association of hypoadiponectinemia with

coronary artery disease in men. Arterioscler Thromb vasc Biol

;23:85–9.

J Ayub Med Coll Abbottabad 2009;21(4)

http://www.ayubmed.edu.pk/JAMC/PAST/21-4/Iram.pdf

Abate N, Chandali M, Snell PG and Grundy SM. Adipose tissue

metabolites and insulin resistance in non diabetic Asian Indian

men. J Clin Endocrinol Metab 2004;89:2750–5.

Mahmud A, Feely J. Adiponectin and arterial stiffness. Am J

Hypertens 2005;18:1543–8.

Matsubara M, Maruoka S, Katayose S. Decreased plasma

adiponectin concentrations in women with dyslipidemia. J Clin

Endocrinol Metab 2002;87:2764–9.

Kistorp C, Faber J, Galatius S, Gustafsson F, Frystyk J,

Flyvbjerg A, et al. Plasma adiponectin, body mass index, and

mortality in patients with chronic heart failure.

Circulation.2005;112:1756–62.

Kojima S, Funahashi T, Sakamoto T, Miyamoto S, Soejima H,

Hokamaki J, et al. The variation of plasma concenterations of a

novel, adipocyte derived protein, adiponectin, in patients with

acute myocardial infarction. Heart 2003; 89:667–8.

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Published

2009-12-01

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