PREVALENCE OF MALIGNANCY IN GOITRE—A REVIEW OF 718 THYROIDECTOMIES
AbstractBackground: Thyroid malignancies are a heterogeneous group of tumours which show considerablevariability in biological behaviour, histological appearances and response to therapy. Thyroid canceris uncommon and represents only 1% of all malignancies. Objective was to determine the prevalenceof malignancy in patients presenting with goitre. This prospective, observational study wasconducted at Department of Surgery, Fauji Foundation Hospital, Rawalpindi from January 1999 toDecember 2008. Methods: All patients requiring surgery for goitre were included in the study.Postoperatively histopathologies of specimens were evaluated in all patients. Results: 718 patientswere operated and post operative histopathology specimens were reviewed. 2.92% of patients werefound to have malignancy. Prevalence of papillary and follicular carcinoma was 33.33% each.Anaplastic carcinoma was found in 23.81% of patients followed by Hurthle cell carcinoma in 9.53%of patients. Conclusion: All postoperative thyroid specimens should be subjected to histopathology.Prevalence of follicular carcinoma and anaplastic carcinoma is relatively higher in our country due tohigh incidence of iodine deficiency goitre.Keywords: Goitre, Malignancy, Prevalence, Carcinoma Thyroid
Thomas WEG. Neoplasm’s of thyroid gland (including the
solitary nodule). Surg Int 2004;64:296–300.
Qureshi JN, Muneer A, Memon AS, Memon S, Hammad A.
Malignancy in nodular goiter. J Surg Pak 2006;11(2):71–2.
Hanks JB. Thyroid. Townsend CM, Beauchamp RD, Evers
BM, Mattox KL (editors) In: Sabiston's Text Book of Surgery
th ed. Philadelphia: Saunders; 2004;961–2.
Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ.
Cancer statistics, 2003, CA Cancer J Clin 2003; 53:5-26.
Wu HS, Young MT, Ituarte PHG, D’Avanzo A, Duh QY,
Greenspan FS, et al. Death from thyroid cancer of Follicular
cell origin. J Am Coll Surg 2000;191:600–6.
Khairy GA. Solitary thyroid nodule: the risk of cancer and the
extent of surgical therapy. East Afr Med J 2004;81:459–62.
Benzarti S, Miled I, Bassoumi T, Ben Mrad B, Akkari K,
Bacha O, Chebbi MK. Thyroid surgery (356cases): risks and
complications. Rev Laryngol Otol Rhinol (Board) 2002;123
Alagic-Smailbegovic J, Kapidzic A, Sutalo K, Resic M, Hadzic
E. Surgical treatment of thyroid gland disease. Med Arh
Prades JM, Dumollard JM, Timoshenko A, Chelikh L, Michel
F, Estour B, et al. Multinodular goiter: surgical management
and histopathological findings. Eur Arch Otolaryngol
Williams ED. Chernobyl, 15 years later: correlation of clinical,
epidemiological and molecular outcomes. Ann Endocrinol
Rossing MA, Voigt LF, Wicklund KG, Daling JR.
Reproductive factors and risk of papillary thyroid cancer in
women. Am J Epidemiol 2000;151:765-72.
Sakoda LC, Horn-Ross PL. Reproductive and menstrual
history and papillary thyroid cancer risk: the San Francisco Bay
Area thyroid cancer study. Cancer Epidemiol Biomarker Prev
Memon A, Darif M, Al Saleh K, Suresh A. Epidemiology of
reproductive and hormonal factors in thyroid cancer: evidence
from a case control study in the Middle East. Int J Cancer
La Vecchia C, Ron E, Franceschi S, Dal Maso L, Mark SD,
Chatenoud L, et al. A pooled analysis of case-control studies of
thyroid cancer. Oral contraceptives, menopausal replacement
therapy and other female hormones. Cancer Causes Control
Duffy BJ, Fitzgerald P. thyroid cancer in childhood and
adolescence: a report on twenty eight cases. Cancer
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.