FREQUENCY AND CLINICAL OUTCOME IN CONDUCTION DEFECTS IN ACUTE MYOCARDIAL INFARCTION
Abstract
Background: Conduction defects complicating acute myocardial infarction (MI) are frequent andassociated with increased mortality and complications. Common conduction defects after acute MIare atrioventricular nodal blocks (1st, 2nd and 3rd degree) and intraventricular conduction defects(right or left bundle branch blocks and hemiblocks). In myocardial infarction occlusion ofcoronary arteries at different levels affects the conduction system of heart leading to various typesof blocks. Conduction defects usually reflect extensive damage to the myocardium. Methods: Inthis descriptive case series with non-probability purposive sampling, 345 cases of acute STelevation myocardial Infarction were studied at Armed Forces Institute of Cardiology/NationalInstitute of Heart Disease, Rawalpindi from May 2007 to May 2008. ECG was continuouslyobserved in CCU and daily ECGs were done. Conduction defects whether transient or persistentwere recorded in pre-designed proforma in addition to other clinical features and associatedcomplications during hospital stay. Results: Out of 345 patients, 251 (72.8%) patients receivedthrombolytic therapy and 61 (17.6%) developed various types of conduction defects (Group A)and 284 had no significant conduction defects (Group B). Isolated complete atrioventricular block(AVB) at the node level occurred in 28 patients (8.1%) mainly in inferior MI. Bundle branchesBlocks occurred in 32 (9.2%) patients mostly in Anterior MI. One patient (0.6%) had completeheart block at bundle branch level. All patients with complete atrioventricular block reverted tosinus rhythm except one who required permanent pacemaker. Mortality rate and clinicalcomplications were higher in group A as compared to group B. Conclusion: Conduction defectsare common even in this thrombolytic era. Patients with conduction defects are at high risk ofinhospital complications and mortality. They need close monitoring and optimum clinical care toreduce mortality and morbidity.Keywords: Conduction defects, Acute myocardial infarction, Bundle branch blocksReferences
Dubois, C, Picrard LA, Smeets JP, Foidart C, Legrand V,
Kulbertus HE. Short & long term prognostic importance of
complete bundle branch block complicating acute myocardial
infarction. Clin Cardiol 1988;11:292–6.
Klein RC, Vera Z, Mason DT. Intraventricular conduction
defects in acute myocardial infarction: Incidence, prognosis,
and therapy. Am Heart J 1984;108:1007–1.
Godman MJ, Lasers BW, Julian DG. Complete bundle
branch block complicating acute myocardial infarction. N
Engl J Med 1970;282:237–40.
Newby KH, Pisano E, Krucoff MW, Green C, Natale A.
Incidence and clinical relevance of the occurrence of bundle
branch block in patients treated with thrombolytic therapy.
Circulation 1996;94:2424–8.
Matetzky S, Novikov M, Gruberg L, Freimark D, Feinberg
M, Elian D, et al. The significance of persistent ST elevation
versus early resolution of ST segment elevation after primary
PTCA. J Am Coll Cardiol 1999;34:1932-8.
Gann D, Balachandran PK, El-Sherif N, Samet P. Prognostic
significance of chronic versus acute bundle branch block in
acute myocardial infarction. Chest 1975;67:298–303.
James TN, Burch GE. Blood supply of the human
intraventricular septum. Circulation 1958;17:391– 6.
Hindman MC, Wagner GS, JaRo M, Atkins JM, Scheiman
MM, DeSanctis RW et al. The clinical significance of bundle
branch block complicating acute myocardial infarction. II.
Indications for temporary and permanent pacemaker
insertion. Circulation 1978;58:689–99.
Scheinman M, Brenman B. Clinical and anatomic
implications of intraventricular conduction block in acute
myocardial infarction. Circulation 1972;46:753–60.
Hindman MC, Wagner GS, JaRo M, Atkins JM, Scheiman
MM, DeSanctis RW et al,. The clinical significance of
bundle branch block complicating acute myocardial
infarction, 1: clinical characteristics, hospital mortality, and
one-year follow-up. Circulation. 1978;58:679–88.
Thygesen K, Alpert JS, White HD. Universal definition of
Myocardial Infarction.J A Coll Cardiol 2007;50:2173–95.
Sgarbossa EB, Pinski SL, Barbagelata A, Underwood DA,
Gates KB, Topol EJ et al, for the GUSTO-1 (Global
Utilization of Streptokinase and Tissue Plasminogen
Activator for Occluded Coronary Arteries) Investigators.
Electrocardiographic diagnosis of evolving acute myocardial
infarction in the presence of left bundle-branch block. N Engl
J Med 1996;334:481–7.
Willems JL, Robles de Medina EO, Bernard R, Coumel P,
Fisch C, Krikler D, et al. Criteria for intraventricular
conduction disturbances and pre-excitation. World Health
Organizational/International Society and Federation for
Cardiology Task Force Ad Hoc. J Am Coll Cardiol
;5:1261–1275.
Rosenbaum MB. The hemiblock, diagnostic criteria and
clinical significance. Mod Concepts Cardiovasc Dis
;39:141–6.
Clemmenson P , Bates ER, Callif RM , Hlatky MA, Aronson
L, George BS, Lee KL et al. Complete atrioventricular block
complicating inferior wall acute myocardial infarction treated
with reperfusion therapy. Am J Cardiol. 1991;64:224–30
Kostuk WJ, Beanlands DS. Complete heart block associated
with acute myocardial infarction. Am J Cardial 1970;26:380–4.
Jones ME, Terry G, Kenmure AC. Frequency and
significance of conduction defects in acute myocardial
infarction. Am Heart J 1977;94:163–7.
Woo KS. Conduction defects in acute myocardial infarction
in the Chinese in Hong Kong. Int J Cardiol 1990;26:325–34.
Archbold RA, Sayer JW, Ray S, Wilkinson P, Ranjadayalan
K, Timmis AD. Frequency and prognostic implications of
conduction defects in acute myocardial infarction since the
introduction of thrombolytic therapy. Eur Heart J
;19:893–8.
Meine TJ, Al-Khatib SM, Alexander JH, Granger CB, White
HD, Kilaru R et al. Incidence, predictors, and outcomes of
high-degree atrioventricular block complicating acute
J Ayub Med Coll Abbottabad 2009;21(3)
http://www.ayubmed.edu.pk/JAMC/PAST/21-3/Bhalli.pdf 37
myocardial infarction treated with thrombolytic therapy. Am
Heart J 2005;149:670–4.
Bilal HB, Sultan J, Hassan K, Ovais K, Majeed I. Heart
blocks as predictors of Mortality in Acute Myocardial
Infarction . J Rawal Med Coll 1999;3(1–2):13–6.
Majumder AA, Malik A, Zafar A. Conduction disturbances
in acute myocardial infarction: Incidence, site-wise
relationship and the influence on in-hospital prognosis.
Bangladesh Med Res Counc Bull.1996;22:74–80.
Escosteguy CC, Carvalho Mde A, Medronho Rde A, Abreu
LM, Monteiro Filho MY. Bundle branch and
atrioventricular block as complications of acute myocardial
infarction in the thrombolytic era. Arq Bras Cardiol
;76:291–6.
Thompson PL, Fletcher EE, Katavatis V. Enzymatic indices
of myocardial necrosis: influence on short- and long-term
prognosis after myocardial infarction. Circulation
;59:113–19.
Opolski G, Kraska T, Ostrzycki A, Zieliński T, Korewicki J.
The effect of infarct size on atrioventricular and
intraventricular conduction disturbances in acute myocardial
infarction. Int J Cardiol.1986;10:141–7.
Nicod P, Gilpin E, Dittrich H, Polikar R, Henning H, Ross J.
Long-term outcome in patients with inferior myocardial
infarction and complete atrioventricular block. J Am Coll
Cardiol 1988;12:589–94.
Coll JJ, Weinberg SL. The incidence and mortality of
intraventricular conduction defects in acute myocardial
infarction. Am J Cardiol 1972;29:344–50.
Downloads
Published
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.