MATERNAL SERUM LEVELS OF ADIPONECTIN IN PREECLAMPSIA

Authors

  • Ali Khosrowbeygi
  • Hassan Ahmadvand

Abstract

Background: The results of the serum levels of adiponectin in preeclamptic patients areconflicting. Objective: The aim of the present study was to assess serum levels of adiponectin inwomen with preeclampsia compared with healthy pregnant women. Methods: A cross-sectionalstudy was designed. The case group consisted of women with preeclampsia (n=30). The controlgroup consisted of 30 matched normal pregnant women. Serum levels of adiponectin wereassessed using enzyme-linked immunosorbent assay method. Results: Serum levels of adiponectinwere significantly higher in the preeclamptic group than those in the normal control group. In thepreeclamptic patients serum levels of adiponectin showed a significant negative correlation withbody mass index while no correlation was found in the normal pregnant women. In women withpreeclampsia, levels of adiponectin were decreased significantly in the overweight womencompared with normal weight women, while in the control group no significant difference wasobserved. Conclusion: In conclusion, elevation of adiponectin levels might be a physiologicalfeedback response to minimize endothelial dysfunction in preeclamptic patients.Keywords: Serum, Adiponectin, Preeclampsia, Pregnancy, BMI, ELISA.

References

Mumtaz F, Memon AR, Yousfani S, Tahir SM, Khushk I,

Memon M, et al. Role of serum leptin level as a marker of

severity of pre eclampsia. J Ayub Med Coll Abbottabad.

;20(1):13–5.

Iftikhar U, Khoja A, Iqbaal MA, Karrira KA. Evaluation of

serum leptin levels during normal pregnancy and in preeclampsia. J Ayub Med Coll Abbottabad 2008;20(4):137–40.

Nakatsukasa H, Masuyama H, Takamoto N, Hiramatsu Y.

Circulating leptin and angiogenic factors in preeclampsia

patients. Endocr J 2008;55:565–73.

Mohaupt M. Molecular aspects of preeclampsia. Mol Aspects

Med 2007;28:169–91

Mutter WP, Karumanchi SA. Molecular mechanisms of

preeclampsia. Microvas Res 2008;75:1–8

Lu D, Yang X, Wu Y, Wang H, Huang H, Dong M. Serum

adiponectin, leptin and soluble leptin receptor in preeclampsia. Int J Gynaecol Obstet 2006;95:121–6.

Takemura Y, Osuga Y, Koga K, Tajima T, Hirota Y, Hirata

T, et al. Selective increase in high molecular weight

adiponectin concentration in serum of women with

preeclampsia. J Reprod Immunol 2007;73:60–65.

Ouyang YQ, Li SJ, Zhang Q, Xiang WP, Shen HL, Chen HP,

et al. Plasma sFlt-1-to-PlGF ratio is correlated with

inflammatory but not with oxidative stress in Chinese

preeclamptic women. Arch Gynecol Obstet. 2009;280:91–7.

Ouyang Y, Chen H, Chen H. Reduced plasma adiponectin

and elevated leptin in pre-eclampsia. Int J Gynaecol Obstet

; 98: 110–14.

Ramsay JE, Jamieson N, Greer IA, Sattar N. Paradoxical

elevation in adiponectin concentrations in women with

preeclampsia. Hypertension 2003;42:891–4.

Kajantie E, Kaaja R, Ylikorkala O, Andersson S, Laivuori H.

Adiponectin concentrations in maternal serum: elevated in

preeclampsia but unrelated to insulin sensitivity. J Soc

Gynecol Investig 2005;12:433–9.

Naruse K, Yamasaki M, Umekage H, Sado T, Sakamoto Y,

Morikawa H. Peripheral blood concentrations of adiponectin,

an adipocyte-specific plasma protein, in normal pregnancy

and preeclampsia. J Reprod Immunol 2005;65:65–75

Nien JK, Mazaki-Tovi S, Romero R, Erez O, Kusanovic JP,

Gotsch F, et al. Adiponectin in severe preeclampsia. J Perinat

Med 2007;35:503–12.

Mazaki-Tovi S, Romero R, Vaisbuch E, Kusanovic JP, Erez

O, Gotsch F, et al. Maternal serum adiponectin multimers in

preeclampsia. J Perinat Med 2009;37:349–63.

J Ayub Med Coll Abbottabad 2009;21(3)

http://www.ayubmed.edu.pk/JAMC/PAST/Ali.pdf

Herse F, Bai Youpeng, Staff AC, Yong-Meid J, Dechend R,

Zhou Rong. Circulating and uteroplacental adipocytokine

concentrations in preeclampsia. Reprod Sci 2009;16:584–90.

Hendler I, Blackwell SC, Mehta SH, Whitty JE, Russell E,

Sorokin Y, et al. The levels of leptin, adiponectin, and

resistin in normal weight, overweight, and obese pregnant

women with and without preeclampsia. Am J Obstet

Gynecol. 2005; 193: 979–83.

Odden N, Henriksen T, Holter E, Grete Skar A, Tjade T, Morkrid

L. Serum adiponectin concentration prior to clinical onset of

preeclampsia. Hypertens Pregnancy 2006;25:129–42.

Marinoni E, Letizia C, Ciardo F, Corona G, Moscarini M, Di

Iorio R. Effects of prenatal betamethasone administration on

leptin and adiponectin concentrations in maternal and fetal

circulation. Am J Obstet Gynecol. 2008;199:141.e1–6

Mazaki-Tovi S, Kanety H, Sivan E. Adiponectin and human

pregnancy. Curr Diab Rep 2005;5:278–81.

Downloads

Published

2009-09-01